Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
Dopamine D2 receptor
D2R D2DR |
| gptkbp:alternativeSplicing |
produces multiple transcript variants
|
| gptkbp:associatedWith |
gptkb:Parkinson's_disease
addiction bipolar disorder schizophrenia Tourette syndrome |
| gptkbp:biologicalProcess |
synaptic transmission
G-protein coupled receptor activity dopamine binding behavioral response to dopamine |
| gptkbp:cellularComponent |
gptkb:plasma_membrane
postsynaptic membrane |
| gptkbp:discoveredBy |
Kebabian and Calne (1979, receptor), gene cloned in 1989
|
| gptkbp:encodes |
D2 subtype of the dopamine receptor
|
| gptkbp:Entrez_Gene_ID |
1813
ENSG00000149295 rs1800497 rs1076560 rs1799732 rs6277 |
| gptkbp:expressedIn |
gptkb:pituitary_gland
brain |
| gptkbp:fullName |
gptkb:Dopamine_receptor_D2
|
| gptkbp:function |
involved in neurotransmission
G protein-coupled receptor for dopamine |
| gptkbp:hasTranscriptVariant |
long isoform
short isoform |
| gptkbp:HGNC_ID |
gptkb:HGNC:3023
|
| gptkbp:length |
8 exons
|
| gptkbp:locatedOnChromosome |
11q23.2
|
| gptkbp:mutationAssociatedWith |
can affect dopamine signaling
|
| gptkbp:OMIM |
126450
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Drd2
|
| gptkbp:product |
Dopamine D2 receptor
|
| gptkbp:proteinFamily |
gptkb:G_protein-coupled_receptor
neurotransmitter receptor |
| gptkbp:regulates |
motor control
reward pathways prolactin secretion |
| gptkbp:targetOfDrug |
antipsychotic drugs
dopamine agonists |
| gptkbp:UniProtID |
P14416
|
| gptkbp:bfsParent |
gptkb:dopamine_receptor_D2
gptkb:dopamine_receptor_family |
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
DRD2 gene
|