DRD2 gene

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias Dopamine D2 receptor
D2R
D2DR
gptkbp:alternativeSplicing produces multiple transcript variants
gptkbp:associatedWith gptkb:Parkinson's_disease
addiction
bipolar disorder
schizophrenia
Tourette syndrome
gptkbp:biologicalProcess synaptic transmission
G-protein coupled receptor activity
dopamine binding
behavioral response to dopamine
gptkbp:cellularComponent gptkb:plasma_membrane
postsynaptic membrane
gptkbp:discoveredBy Kebabian and Calne (1979, receptor), gene cloned in 1989
gptkbp:encodes D2 subtype of the dopamine receptor
gptkbp:Entrez_Gene_ID 1813
ENSG00000149295
rs1800497
rs1076560
rs1799732
rs6277
gptkbp:expressedIn gptkb:pituitary_gland
brain
gptkbp:fullName gptkb:Dopamine_receptor_D2
gptkbp:function involved in neurotransmission
G protein-coupled receptor for dopamine
gptkbp:hasTranscriptVariant long isoform
short isoform
gptkbp:HGNC_ID gptkb:HGNC:3023
https://www.w3.org/2000/01/rdf-schema#label DRD2 gene
gptkbp:length 8 exons
gptkbp:locatedOnChromosome 11q23.2
gptkbp:mutationAssociatedWith can affect dopamine signaling
gptkbp:OMIM 126450
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse Drd2
gptkbp:product Dopamine D2 receptor
gptkbp:proteinFamily gptkb:G_protein-coupled_receptor
neurotransmitter receptor
gptkbp:regulates motor control
reward pathways
prolactin secretion
gptkbp:targetOfDrug antipsychotic drugs
dopamine agonists
gptkbp:UniProtID P14416
gptkbp:bfsParent gptkb:dopamine_receptor_D2
gptkbp:bfsLayer 7