|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvalYear
|
1899
|
|
gptkbp:ATCCode
|
gptkb:N02BA01
B01AC06
|
|
gptkbp:bioavailability
|
80-100%
|
|
gptkbp:CASNumber
|
50-78-2
|
|
gptkbp:contraindication
|
Active peptic ulcer
Hypersensitivity to NSAIDs
Children with viral infections (risk of Reye's syndrome)
|
|
gptkbp:drugInteraction
|
gptkb:Warfarin
gptkb:Methotrexate
gptkb:Ibuprofen
ACE inhibitors
|
|
gptkbp:eliminationHalfLife
|
15-30 hours (high dose)
2-3 hours (low dose)
|
|
gptkbp:excretion
|
Renal
|
|
gptkbp:hasDrugBankCategory
|
gptkb:Antiplatelet_agent
analgesic
Antipyretic
nonsteroidal anti-inflammatory drug
|
|
gptkbp:hasInChIKey
|
BSYNRYMUTXBXSQ-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C9H8O4
|
|
gptkbp:hasSMILES
|
CC(=O)Oc1ccccc1C(=O)O
|
|
gptkbp:hasUNII
|
R16CO5Y76E
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB00107
|
|
gptkbp:indication
|
gptkb:Pain
Fever
Inflammation
Prevention of myocardial infarction
Prevention of stroke
|
|
gptkbp:legalStatus
|
gptkb:OTC
|
|
gptkbp:manufacturer
|
gptkb:Bayer
|
|
gptkbp:mechanismOfAction
|
Inhibits cyclooxygenase (COX-1 and COX-2)
|
|
gptkbp:metabolism
|
Hepatic
|
|
gptkbp:molecularWeight
|
180.16 g/mol
|
|
gptkbp:name
|
gptkb:Aspirin
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:proteinBinding
|
80-90%
|
|
gptkbp:PubChem_CID
|
2244
CHEMBL25
D00109
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Rectal
Intravenous
|
|
gptkbp:sideEffect
|
Bleeding
Allergic reaction
Tinnitus
Gastrointestinal ulcer
|
|
gptkbp:synonym
|
gptkb:ASA
gptkb:Acetylsalicylic_acid
|
|
gptkbp:target
|
gptkb:PTGS2
gptkb:Prostaglandin-endoperoxide_synthase_2
gptkb:PTGS1
gptkb:Prostaglandin-endoperoxide_synthase_1
|
|
gptkbp:bfsParent
|
gptkb:Oxytocin
gptkb:oxytocin
|
|
gptkbp:bfsLayer
|
7
|