|
gptkbp:instance_of
|
gptkb:drug
|
|
gptkbp:activities
|
gptkb:fragrance
|
|
gptkbp:affects
|
cell proliferation
DNA synthesis
|
|
gptkbp:appointed_by
|
injection
oral tablet
|
|
gptkbp:approves
|
gptkb:FDA
1953
|
|
gptkbp:brand
|
gptkb:Rheumatrex
gptkb:Trexall
|
|
gptkbp:contraindication
|
alcoholism
liver disease
pregnancy
immunodeficiency
|
|
gptkbp:developed_by
|
gptkb:University
|
|
gptkbp:discovered_by
|
1940s
|
|
gptkbp:dosage_form
|
gptkb:software_framework
gptkb:tablet
|
|
gptkbp:excretion
|
urine
feces
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Methotrexate
|
|
gptkbp:ingredients
|
C20 H22 N8 O5 S
|
|
gptkbp:interacts_with
|
live vaccines
penicillins
probenecid
NSAI Ds
sulfonamides
|
|
gptkbp:is_atype_of
|
L01 B A01
|
|
gptkbp:is_available_on
|
generic drug
|
|
gptkbp:is_used_for
|
gptkb:healthcare_organization
gptkb:rheumatoid_arthritis
psoriasis
|
|
gptkbp:lifespan
|
3 to 10 hours
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:side_effect
|
fatigue
nausea
liver toxicity
bone marrow suppression
mouth sores
|
|
gptkbp:storage
|
room temperature
protected from light
|
|
gptkbp:type_of
|
59-05-2
|
|
gptkbp:used_in
|
gptkb:Crohn's_disease
gptkb:ulcerative_colitis
autoimmune diseases
ectopic pregnancy
high-dose chemotherapy
|
|
gptkbp:bfsParent
|
gptkb:Vitamin_B9
|
|
gptkbp:bfsLayer
|
5
|