|
gptkbp:instanceOf
|
gptkb:drug
Antimetabolite
Chemotherapy agent
Immunosuppressant
|
|
gptkbp:antidote
|
Leucovorin
|
|
gptkbp:approvedBy
|
gptkb:FDA
1953
|
|
gptkbp:ATCCode
|
L01BA01
|
|
gptkbp:brand
|
gptkb:Otrexup
gptkb:Rheumatrex
gptkb:Trexall
Rasuvo
|
|
gptkbp:CASNumber
|
59-05-2
|
|
gptkbp:contraindication
|
gptkb:liver_disease
gptkb:Pregnancy
Alcoholism
|
|
gptkbp:discoveredBy
|
gptkb:Sidney_Farber
|
|
gptkbp:drugInteraction
|
gptkb:NSAIDs
gptkb:Trimethoprim
Proton pump inhibitors
Penicillins
|
|
gptkbp:eliminationHalfLife
|
3 to 10 hours
|
|
gptkbp:excretion
|
Renal
|
|
gptkbp:hasMolecularFormula
|
C20H22N8O5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Methotrexate
|
|
gptkbp:legalStatus
|
Prescription only
|
|
gptkbp:mechanismOfAction
|
Inhibits dihydrofolate reductase
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:pregnancyCategory
|
X (contraindicated)
|
|
gptkbp:PubChem_CID
|
CHEMBL654
126941
DB00563
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Intramuscular
Intravenous
Subcutaneous
|
|
gptkbp:sideEffect
|
gptkb:Nausea
Fatigue
Liver toxicity
Hair loss
Mouth ulcers
Bone marrow suppression
|
|
gptkbp:UNII
|
YL5FZ2Y5U1
|
|
gptkbp:usedFor
|
gptkb:cancer
gptkb:Systemic_lupus_erythematosus
gptkb:Crohn's_disease
Psoriasis
Ectopic pregnancy
Rheumatoid arthritis
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
Yes
|
|
gptkbp:bfsParent
|
gptkb:MTX
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|