nonsteroidal anti-inflammatory drug
GPTKB entity
Statements (44)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
|
| gptkbp:alternativeName |
COX-2_inhibitor
Nonsteroidal_anti-inflammatory_drug |
| gptkbp:alternativeTo |
traditional NSAIDs
|
| gptkbp:approvedBy |
late 1990s
|
| gptkbp:category |
nonsteroidal anti-inflammatory drug (NSAID)
|
| gptkbp:contraindication |
history of cardiovascular disease
allergy to sulfonamides |
| gptkbp:contrastsWith |
nonselective NSAIDs
|
| gptkbp:discoveredBy |
researchers at pharmaceutical companies
|
| gptkbp:eliminatedIn |
gptkb:kidney
|
| gptkbp:example |
gptkb:parecoxib
gptkb:valdecoxib gptkb:etoricoxib gptkb:rofecoxib gptkb:celecoxib |
| gptkbp:lessLikelyToCause |
gastrointestinal ulcers
|
| gptkbp:mayIncreaseRiskOf |
cardiovascular events
|
| gptkbp:mechanismOfAction |
selective inhibition of cyclooxygenase-2
|
| gptkbp:metabolism |
liver
|
| gptkbp:notRecommendedFor |
coronary artery disease
stroke history |
| gptkbp:notTarget |
COX-1 enzyme
|
| gptkbp:reduces |
prostaglandin synthesis
|
| gptkbp:regulates |
prescription only
|
| gptkbp:routeOfAdministration |
oral
intravenous |
| gptkbp:sideEffect |
edema
headache hypertension dyspepsia renal impairment |
| gptkbp:target |
COX-2 enzyme
|
| gptkbp:usedFor |
osteoarthritis
pain relief rheumatoid arthritis inflammation reduction acute pain ankylosing spondylitis menstrual pain |
| gptkbp:withdrawnDrug |
gptkb:valdecoxib
gptkb:rofecoxib |
| gptkbp:bfsParent |
gptkb:Voltaren
|
| gptkbp:bfsLayer |
5
|