|
gptkbp:instanceOf
|
gptkb:enzyme
cytochrome P450 enzyme
|
|
gptkbp:alternativeName
|
gptkb:CYP3A4
cytochrome P450 3A4
CYP3A subfamily member 4
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:EC_number
|
1.14.14.1
|
|
gptkbp:expressedIn
|
liver
intestine
|
|
gptkbp:foundIn
|
gptkb:small_intestine
human liver
|
|
gptkbp:function
|
drug metabolism
xenobiotic metabolism
|
|
gptkbp:gene
|
gptkb:CYP3A4
|
|
gptkbp:HGNC_ID
|
2623
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P450 3A4
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
gptkb:St._John's_Wort
|
|
gptkbp:inhibitedBy
|
gptkb:clarithromycin
gptkb:ketoconazole
itraconazole
|
|
gptkbp:locatedOnChromosome
|
7q22.1
|
|
gptkbp:metabolism
|
over 50% of clinically used drugs
|
|
gptkbp:molecularWeight
|
57 kDa
|
|
gptkbp:OMIM
|
124010
|
|
gptkbp:PDB
|
1TQN
|
|
gptkbp:proteinFamily
|
gptkb:CYP3A
|
|
gptkbp:RefSeq
|
NM_017460
|
|
gptkbp:related_enzyme
|
gptkb:CYP3A5
gptkb:CYP3A43
gptkb:CYP3A7
|
|
gptkbp:significance
|
pharmacogenomics
drug-drug interactions
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains heme prosthetic group
|
|
gptkbp:substrate
|
gptkb:cyclosporine
gptkb:nifedipine
gptkb:lidocaine
gptkb:tamoxifen
gptkb:erythromycin
gptkb:midazolam
statins
alprazolam
testosterone
|
|
gptkbp:tissue_specificity
|
high in liver
present in small intestine
|
|
gptkbp:UniProtID
|
P08684
|
|
gptkbp:bfsParent
|
gptkb:Cytochrome_P450_3A4
|
|
gptkbp:bfsLayer
|
6
|