|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
no
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
serine/threonine-protein kinase activity
DNA replication
G1/S transition of mitotic cell cycle
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:ensembl
|
ENSG00000123374
|
|
gptkbp:Entrez_Gene_ID
|
1017
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.22
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_2
|
|
gptkbp:function
|
regulation of cell cycle
|
|
gptkbp:gene
|
gptkb:CDK2
|
|
gptkbp:GO
|
GO:0006281
GO:0000082
GO:0004693
|
|
gptkbp:HGNC_ID
|
HGNC:1771
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cdk2
|
|
gptkbp:inhibitedBy
|
gptkb:purvalanol_A
gptkb:p21
gptkb:p27
gptkb:roscovitine
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_A
gptkb:Cyclin_E
|
|
gptkbp:length
|
298 amino acids
|
|
gptkbp:locatedOnChromosome
|
12q13
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Drosophila_melanogaster
Mus musculus (mouse)
Rattus norvegicus (rat)
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk2
|
|
gptkbp:pathway
|
Cell cycle (KEGG: hsa04110)
DNA replication (KEGG: hsa03030)
p53 signaling pathway (KEGG: hsa04115)
|
|
gptkbp:PDB
|
1FIN
|
|
gptkbp:phosphorylates
|
Thr160
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:RefSeq
|
gptkb:NP_001789.2
|
|
gptkbp:regulates
|
gptkb:E2F_transcription_factors
Rb protein phosphorylation
|
|
gptkbp:relatedTo
|
gptkb:Cdk4
gptkb:Cdk1
|
|
gptkbp:requires
|
cell proliferation
|
|
gptkbp:structure
|
monomer
heterodimer with cyclins
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P24941
|
|
gptkbp:bfsParent
|
gptkb:CDK2_gene
gptkb:mouse_Cdk2
gptkb:rat_Cdk2
|
|
gptkbp:bfsLayer
|
8
|