|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activity
|
oxidation
hydroxylation
epoxidation
deamination
dealkylation
dehalogenation
|
|
gptkbp:alternativeName
|
P450 enzymes
cytochrome P450 monooxygenases
microsomal monooxygenases
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:contains
|
gptkb:CYP1_family
gptkb:CYP2_family
gptkb:CYP3_family
gptkb:CYP4_family
|
|
gptkbp:discoveredBy
|
gptkb:Osamu_Hayaishi
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:EC_number
|
1.14.-.-
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
fungi
plants
|
|
gptkbp:fullName
|
Cytochrome P450 enzymes
|
|
gptkbp:function
|
catalyze oxidation of organic substances
|
|
gptkbp:geneSymbolPrefix
|
CYP
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP enzymes
|
|
gptkbp:importantMember
|
gptkb:CYP1A2
gptkb:CYP2C9
gptkb:CYP2C19
gptkb:CYP2D6
gptkb:CYP3A4
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:carbamazepine
|
|
gptkbp:inhibitedBy
|
gptkb:milk
azole antifungals
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
mitochondria
|
|
gptkbp:mechanismOfAction
|
monooxygenase activity
|
|
gptkbp:nomenclatureAuthority
|
gptkb:International_Union_of_Biochemistry_and_Molecular_Biology
|
|
gptkbp:role
|
synthesis of cholesterol
drug metabolism
synthesis of steroids
synthesis of lipids
|
|
gptkbp:significance
|
pharmacogenomics
adverse drug reactions
drug-drug interactions
|
|
gptkbp:structure
|
contains iron
contains heme prosthetic group
|
|
gptkbp:substrate
|
xenobiotics
endogenous compounds
|
|
gptkbp:superfamily
|
gptkb:Cytochrome_P450
|
|
gptkbp:bfsParent
|
gptkb:hepatocytes
|
|
gptkbp:bfsLayer
|
6
|