|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CYP2D6
gptkb:debrisoquine_4-hydroxylase
P450-DB1
|
|
gptkbp:associatedWith
|
adverse drug reaction
treatment failure
drug toxicity
poor metabolizer phenotype
ultrarapid metabolizer phenotype
breast cancer (via tamoxifen metabolism)
pain management (via codeine metabolism)
extensive metabolizer phenotype
intermediate metabolizer phenotype
|
|
gptkbp:database
|
gptkb:GeneCards
gptkb:ClinVar
gptkb:dbSNP
gptkb:PharmGKB
|
|
gptkbp:discoveredBy
|
Ulrike M. Zanger
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodes
|
gptkb:cytochrome_P450_2D6
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100197
1565
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.1
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:small_intestine
brain
liver
|
|
gptkbp:function
|
drug metabolism
oxidation of xenobiotics
metabolism of antidepressants
metabolism of antipsychotics
metabolism of beta blockers
metabolism of opioids
metabolism of tamoxifen
|
|
gptkbp:gene
|
gptkb:CYP2D6
|
|
gptkbp:geneCluster
|
CYP2D cluster on chromosome 22
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:hasPolymorphism
|
true
|
|
gptkbp:hasPseudogene
|
gptkb:CYP2D7
gptkb:CYP2D8P
CYP2D9P
|
|
gptkbp:HGNC_ID
|
HGNC:2625
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2D6 (human)
|
|
gptkbp:inducedBy
|
none known
|
|
gptkbp:inhibitedBy
|
gptkb:paroxetine
gptkb:bupropion
gptkb:fluoxetine
cimetidine
quinidine
|
|
gptkbp:length
|
497 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q13.2
chromosome 22
|
|
gptkbp:memberOf
|
gptkb:protein
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:numberOfAlleles
|
over 100
|
|
gptkbp:OMIM
|
124030
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2d1
gptkb:Cyp2d22
|
|
gptkbp:proteinFamily
|
gptkb:CYP2D_subfamily
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:significance
|
pharmacogenomics
adverse drug reactions
variable drug response
|
|
gptkbp:substrate
|
gptkb:tricyclic_antidepressants
gptkb:dextromethorphan
gptkb:codeine
gptkb:SSRIs
gptkb:tamoxifen
beta blockers
antipsychotics
|
|
gptkbp:UniProtID
|
P10635
|
|
gptkbp:bfsParent
|
gptkb:Cyp2d1
gptkb:Cyp2d22
|
|
gptkbp:bfsLayer
|
6
|