|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:cytochrome_P450_2C19
P450IIC19
|
|
gptkbp:associatedWith
|
poor metabolizer phenotype
ultrarapid metabolizer phenotype
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:EC_number
|
1.14.13.13
|
|
gptkbp:encodedBy
|
gptkb:CYP2C19_gene
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
liver
|
|
gptkbp:function
|
monooxygenase activity
drug metabolism
|
|
gptkbp:hasPolymorphism
|
affects drug metabolism
|
|
gptkbp:HGNC_ID
|
2621
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2C19 protein
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:carbamazepine
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:fluvoxamine
gptkb:fluconazole
gptkb:omeprazole
gptkb:ticlopidine
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q23.33
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:memberOf
|
gptkb:protein
|
|
gptkbp:molecularWeight
|
approximately 56 kDa
|
|
gptkbp:mutationAssociatedWith
|
altered drug response
|
|
gptkbp:OMIM
|
124020
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cyp2c11
gptkb:Cyp2c29
|
|
gptkbp:pathway
|
xenobiotic metabolism
drug metabolism - cytochrome P450
|
|
gptkbp:PDB
|
4GQS
|
|
gptkbp:RefSeq
|
NP_000760.1
|
|
gptkbp:significance
|
pharmacogenomics
|
|
gptkbp:substrate
|
gptkb:omeprazole
gptkb:clopidogrel
gptkb:diazepam
gptkb:mephenytoin
gptkb:proguanil
|
|
gptkbp:UniProtID
|
gptkb:P33261
|
|
gptkbp:bfsParent
|
gptkb:P42DC
|
|
gptkbp:bfsLayer
|
7
|