|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alsoKnownAs
|
gptkb:SDF-1
gptkb:stromal_cell-derived_factor_1
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:discoveredBy
|
gptkb:Tashiro_et_al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:CXCL12_gene
|
|
gptkbp:Entrez_Gene_ID
|
6387
|
|
gptkbp:expressedIn
|
various tissues
endothelial cells
bone marrow stromal cells
|
|
gptkbp:function
|
chemokine activity
chemoattractant
immune cell migration
regulation of hematopoiesis
|
|
gptkbp:GOProcess
|
immune response
cell chemotaxis
|
|
gptkbp:hasIsoform
|
gptkb:CXCL12-α
gptkb:CXCL12-β
gptkb:CXCL12-γ
gptkb:CXCL12-δ
gptkb:CXCL12-ε
gptkb:CXCL12-φ
|
|
gptkbp:HGNC_ID
|
10672
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CXCL12
|
|
gptkbp:involvedIn
|
embryonic development
angiogenesis
cancer metastasis
|
|
gptkbp:length
|
89
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
|
|
gptkbp:molecularWeight
|
10 kDa
|
|
gptkbp:OMIM
|
600835
|
|
gptkbp:orthologIn
|
present in mouse
present in other mammals
present in rat
|
|
gptkbp:pathway
|
gptkb:hematopoietic_cell_lineage
axon guidance
chemokine signaling pathway
HIV infection pathway
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
|
gptkbp:product
|
secreted protein
|
|
gptkbp:recipient
|
gptkb:CXCR4
gptkb:ACKR3
|
|
gptkbp:significance
|
HIV infection
cancer progression
inflammatory diseases
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains four conserved cysteine residues
|
|
gptkbp:UniProtID
|
gptkb:P48061
|
|
gptkbp:bfsParent
|
gptkb:SDF-1
gptkb:CXCR4_co-receptor
gptkb:CXCR4
|
|
gptkbp:bfsLayer
|
7
|