|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:antigenicVariation
|
high
|
|
gptkbp:binds
|
gptkb:CD4_receptor
CCR5 coreceptor
CXCR4 coreceptor
|
|
gptkbp:component
|
HIV-1 envelope protein complex
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:env_gene
|
|
gptkbp:exposedBy
|
surface of HIV-1 virion
|
|
gptkbp:formsComplexWith
|
gptkb:gp41
|
|
gptkbp:foundIn
|
gptkb:HIV-1
|
|
gptkbp:function
|
mediates viral entry into host cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIV-1 gp120
|
|
gptkbp:inhibitedBy
|
ibalizumab
fostemsavir
maraviroc (CCR5 antagonist)
|
|
gptkbp:interactsWith
|
host immune system
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:postTranslationalModification
|
N-linked glycosylation
|
|
gptkbp:recognizedBy
|
gptkb:CD4+_T_cells
gptkb:B_cells
monoclonal antibodies
|
|
gptkbp:role
|
immune evasion
HIV pathogenesis
cell tropism determination
syncytium formation
|
|
gptkbp:structure
|
heavily glycosylated
variable loops (V1-V5)
|
|
gptkbp:target
|
neutralizing antibodies
HIV vaccine research
|
|
gptkbp:usedIn
|
diagnostic assays
|
|
gptkbp:bfsParent
|
gptkb:CXCR4
|
|
gptkbp:bfsLayer
|
7
|