C-X-C chemokine receptor type 4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:G_protein-coupled_receptor
gptkbp:alternativeName	gptkb:CD184 fusin
gptkbp:discoveredBy	1996
gptkbp:Entrez_Gene_ID	ENSG00000121966
gptkbp:expressedIn	gptkb:neurons hematopoietic cells endothelial cells
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	gptkb:chemokine_receptor
gptkbp:gene	gptkb:CXCR4
gptkbp:HGNC_ID	HGNC:2561
gptkbp:length	352
gptkbp:ligand	gptkb:CXCL12
gptkbp:locatedOnChromosome	2q22.1
gptkbp:location	gptkb:cell_membrane
gptkbp:molecularWeight	39 kDa
gptkbp:OMIM	162643
gptkbp:orthologInMouse	gptkb:Cxcr4
gptkbp:orthologInZebrafish	cxcr4b
gptkbp:pathway	gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway chemokine signaling pathway HIV infection pathway
gptkbp:PDB	3ODU 3OE0 4RWS
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:RefSeq	NM_003467
gptkbp:role	gptkb:WHIM_syndrome HIV infection hematopoiesis cardiac development vascular development cancer metastasis
gptkbp:role_in_immune_system	lymphocyte migration stem cell homing leukocyte trafficking
gptkbp:structure	seven transmembrane domains
gptkbp:targetOfDrug	gptkb:AMD3100 gptkb:plerixafor
gptkbp:UniProtID	P61073
gptkbp:bfsParent	gptkb:CXCR4
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	C-X-C chemokine receptor type 4