C-X-C chemokine receptor type 4

URI: https://gptkb.org/entity/C-X-C_chemokine_receptor_type_4
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:G_protein-coupled_receptor
gptkbp:alternativeName gptkb:CD184
fusin
gptkbp:discoveredBy 1996
gptkbp:Entrez_Gene_ID ENSG00000121966
gptkbp:expressedIn neurons
hematopoietic cells
endothelial cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function chemokine receptor
gptkbp:gene gptkb:CXCR4
gptkbp:HGNC_ID HGNC:2561
https://www.w3.org/2000/01/rdf-schema#label C-X-C chemokine receptor type 4
gptkbp:length 352
gptkbp:ligand gptkb:CXCL12
gptkbp:locatedOnChromosome 2q22.1
gptkbp:location gptkb:cell_membrane
gptkbp:molecularWeight 39 kDa
gptkbp:OMIM 162643
gptkbp:orthologInMouse gptkb:Cxcr4
gptkbp:orthologInZebrafish cxcr4b
gptkbp:pathway gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
chemokine signaling pathway
HIV infection pathway
gptkbp:PDB 3ODU
3OE0
4RWS
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:RefSeq NM_003467
gptkbp:role gptkb:WHIM_syndrome
HIV infection
hematopoiesis
cardiac development
vascular development
cancer metastasis
gptkbp:role_in_immune_system lymphocyte migration
stem cell homing
leukocyte trafficking
gptkbp:structure seven transmembrane domains
gptkbp:targetOfDrug gptkb:AMD3100
gptkb:plerixafor
gptkbp:UniProtID P61073
gptkbp:bfsParent gptkb:CXCR4
gptkbp:bfsLayer 7