|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CDKN4
gptkb:p27Kip1
|
|
gptkbp:associatedWith
|
tumor suppression
|
|
gptkbp:degradedBy
|
SCF(Skp2) complex
|
|
gptkbp:downregulatedIn
|
various cancers
|
|
gptkbp:encodes
|
gptkb:p27Kip1
|
|
gptkbp:Entrez_Gene_ID
|
1027
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:HGNC_ID
|
HGNC:1785
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDKN1B (p27)
|
|
gptkbp:inhibitedBy
|
cyclin-dependent kinase
|
|
gptkbp:interactsWith
|
gptkb:cyclin_A
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:cyclin_E
|
|
gptkbp:involvedIn
|
cellular senescence
cell cycle arrest
tumorigenesis
TGF-beta signaling
response to DNA damage
contact inhibition
|
|
gptkbp:length
|
198 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13
|
|
gptkbp:molecularWeight
|
22 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:multiple_endocrine_neoplasia_type_4
|
|
gptkbp:OMIM
|
600778
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1b
|
|
gptkbp:orthologInZebrafish
|
cdkn1ba
|
|
gptkbp:PDB
|
1JSU
2AST
|
|
gptkbp:phosphorylates
|
gptkb:CDK2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:TGF-beta_pathway
gptkb:PI3K/AKT_pathway
apoptosis
cell differentiation
cell proliferation
cell cycle
G1 phase
miRNAs
FoxO transcription factors
Skp2
|
|
gptkbp:structure
|
contains a cyclin-dependent kinase inhibitor domain
|
|
gptkbp:UniProtID
|
P46527
|
|
gptkbp:bfsParent
|
gptkb:CDK2_gene
|
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gptkbp:bfsLayer
|
8
|