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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:cell_division_protein_kinase_2
gptkb:p33(CDK2)
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gptkbp:associatedWith
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gptkb:Alzheimer's_disease
gptkb:cancer
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gptkbp:Entrez_Gene_ID
|
1017
ENSG00000123374
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gptkbp:enzymeClassification
|
EC 2.7.11.22
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gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_2
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gptkbp:function
|
Serine/threonine-protein kinase involved in cell cycle regulation
Regulates G1/S and S phase transitions
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gptkbp:gene
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gptkb:CDK2
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gptkbp:GO_term
|
GO:0005524 (ATP binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005634 (nucleus)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
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|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK2 HUMAN
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gptkbp:inhibitedBy
|
gptkb:purvalanol_A
gptkb:flavopiridol
gptkb:roscovitine
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gptkbp:interactsWith
|
gptkb:CDKN1A_(p21)
gptkb:CDKN1B_(p27)
gptkb:Cyclin_A
gptkb:Cyclin_E
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|
gptkbp:locatedOnChromosome
|
12q13
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
33 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
CDK2_MOUSE
CDK2_RAT
|
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gptkbp:pathway
|
DNA replication
Cell cycle
p53 signaling pathway
|
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gptkbp:PDB
|
gptkb:1HCK
1FIN
|
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gptkbp:phosphorylates
|
Thr160
Tyr15
Thr14
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
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gptkbp:RefSeq
|
gptkb:NP_001789.2
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
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gptkbp:sequence
|
298 amino acids
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P24941
|
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gptkbp:bfsParent
|
gptkb:P34130
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gptkbp:bfsLayer
|
8
|