flavopiridol

GPTKB entity

Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkb:drug
gptkbp:administeredBy intravenous infusion
gptkbp:ATCCode none
gptkbp:CASNumber 146426-40-6
gptkbp:clinicalTrialPhase Phase II
gptkbp:color yellow
gptkbp:developedBy anticancer agent
gptkbp:discoveredBy gptkb:Hoechst_Marion_Roussel
gptkbp:hasInChIKey QBUVFDKTZJNUPP-ZDUSSCGKSA-N
gptkbp:hasMolecularFormula C21H20ClNO5
gptkbp:hasSMILES CN1CCC[C@H]1C2=CC(=O)C3=C(O2)C=C(C=C3O)C4=CC=CC=C4Cl
gptkbp:hasUNII 8N3DW7272P
https://www.w3.org/2000/01/rdf-schema#label flavopiridol
gptkbp:isApprovedDrug true
gptkbp:isApprovedForUse not FDA approved
gptkbp:isCytotoxic true
gptkbp:isOralBioavailable low
gptkbp:isSynthetic true
gptkbp:IUPACName 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
gptkbp:mechanismOfAction cyclin-dependent kinase inhibitor
gptkbp:meltingPoint >200°C
gptkbp:molecularWeight 401.84 g/mol
gptkbp:origin synthetic derivative of rohitukine
gptkbp:PubChem_CID gptkb:CHEMBL297
DB01205
5287969
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
diarrhea
fatigue
neutropenia
gptkbp:synonym HMR 1275
L86-8275
NSC 649890
alvocidib
gptkbp:target gptkb:CDK9
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:CDK1
gptkbp:usedInTreatmentOf gptkb:acute_myeloid_leukemia
chronic lymphocytic leukemia
solid tumors
gptkbp:bfsParent gptkb:cdc2
gptkbp:bfsLayer 5