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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alsoKnownAs
|
gptkb:CD4
|
|
gptkbp:binds
|
gptkb:MHC_class_II_molecules
|
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gptkbp:discoveredIn
|
1980s
|
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gptkbp:encodedBy
|
gptkb:CD4_gene
|
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gptkbp:expressedIn
|
dendritic cells
macrophages
monocytes
T helper cells
|
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gptkbp:extracellularDomains
|
4 immunoglobulin-like domains
|
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gptkbp:foundIn
|
humans
other mammals
|
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gptkbp:function
|
coreceptor for T cell receptor
mediates immune response
|
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gptkbp:glycosylation
|
N-linked glycosylation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD4 glycoprotein
|
|
gptkbp:interactsWith
|
Lck tyrosine kinase
|
|
gptkbp:locatedOn
|
surface of immune cells
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_12_(human)
|
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gptkbp:molecularWeight
|
approximately 55 kDa
|
|
gptkbp:PDB
|
1WIP
|
|
gptkbp:role
|
HIV infection
|
|
gptkbp:significance
|
CD4 count used to monitor HIV/AIDS progression
|
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gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
single-chain transmembrane glycoprotein
|
|
gptkbp:target
|
gptkb:HIV
|
|
gptkbp:UniProtID
|
P01730
|
|
gptkbp:usedAs
|
marker for T helper cells
|
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gptkbp:bfsParent
|
gptkb:CD4+_T_cells
|
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gptkbp:bfsLayer
|
6
|