|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:antigenProcessingPathway
|
exogenous pathway
|
|
gptkbp:associatedWith
|
autoimmune diseases
|
|
gptkbp:binds
|
invariant chain during synthesis
peptide antigens
|
|
gptkbp:cleavage
|
cathepsins
|
|
gptkbp:composedOf
|
alpha chain
beta chain
|
|
gptkbp:deficiencyCauses
|
gptkb:bare_lymphocyte_syndrome_type_II
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
gptkb:MHC_class_II_genes
|
|
gptkbp:example
|
gptkb:HLA-DP
gptkb:HLA-DQ
gptkb:HLA-DR
|
|
gptkbp:expressedIn
|
gptkb:B_cells
dendritic cells
macrophages
antigen-presenting cells
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
antigen presentation
|
|
gptkbp:hasPolymorphism
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC class II molecules
|
|
gptkbp:importantFor
|
vaccine response
|
|
gptkbp:interactsWith
|
gptkb:CD4_molecule
|
|
gptkbp:involvedIn
|
adaptive immune response
transplant rejection
|
|
gptkbp:locatedOn
|
cell surface
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6_(human)
gptkb:chromosome_17_(mouse)
|
|
gptkbp:peptideBindingGroove
|
open at both ends
|
|
gptkbp:peptideLength
|
13-25 amino acids
|
|
gptkbp:peptideLoading
|
occurs in endosome
|
|
gptkbp:presentAntigenTo
|
gptkb:CD4+_T_cells
|
|
gptkbp:recognizedBy
|
cell surface receptor
|
|
gptkbp:regulates
|
cytokines
|
|
gptkbp:role
|
gptkb:allergy
T cell activation
antibody production
immune tolerance
helper T cell differentiation
immune memory
pathogen recognition
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
|
|
gptkbp:stable
|
gptkb:HLA-DM
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:upregulatedBy
|
gptkb:interferon-gamma
|
|
gptkbp:bfsParent
|
gptkb:major_histocompatibility_complex_(MHC)
gptkb:B_cells
|
|
gptkbp:bfsLayer
|
6
|