|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
gptkb:DPP4
|
|
gptkbp:cellSurfaceMarker
|
gptkb:T_cells
endothelial cells
epithelial cells
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:EC_number
|
3.4.14.5
|
|
gptkbp:encodedBy
|
DPP4 gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
liver
intestine
immune cells
|
|
gptkbp:form
|
homodimer
|
|
gptkbp:fullName
|
gptkb:Dipeptidyl_peptidase-4
|
|
gptkbp:function
|
regulates glucose metabolism
cleaves dipeptides from polypeptides
involved in immune regulation
|
|
gptkbp:gene
|
gptkb:DPP4
|
|
gptkbp:glycosylation
|
yes
|
|
gptkbp:HGNC_ID
|
3009
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD26
|
|
gptkbp:inhibitedBy
|
gptkb:alogliptin
gptkb:sitagliptin
gptkb:saxagliptin
gptkb:vildagliptin
|
|
gptkbp:interactsWith
|
gptkb:fibronectin
gptkb:adenosine_deaminase
|
|
gptkbp:locatedOnChromosome
|
gptkb:2q24.2
|
|
gptkbp:location
|
gptkb:cell_membrane
soluble form in plasma
|
|
gptkbp:medicalUse
|
target for type 2 diabetes drugs
|
|
gptkbp:molecularWeight
|
110 kDa
|
|
gptkbp:OMIM
|
102720
|
|
gptkbp:orthologInMouse
|
Dpp4
|
|
gptkbp:PDB
|
gptkb:1ORV
|
|
gptkbp:role
|
gptkb:cancer
gptkb:type_2_diabetes
HIV infection
autoimmune diseases
inflammatory diseases
|
|
gptkbp:significance
|
biomarker for some cancers
involved in HIV infection
|
|
gptkbp:structure
|
type II transmembrane glycoprotein
|
|
gptkbp:substrate
|
gptkb:GLP-1
gptkb:GIP
chemokines
neuropeptides
|
|
gptkbp:UniProtID
|
gptkb:P27487
|
|
gptkbp:bfsParent
|
gptkb:DPP-4_enzyme
|
|
gptkbp:bfsLayer
|
7
|