|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alias
|
gptkb:Aminopeptidase
ADCP2
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes_mellitus
HIV infection
|
|
gptkbp:cleavage
|
Xaa-Ala dipeptides
Xaa-Pro dipeptides
|
|
gptkbp:discoveredBy
|
Hopsu-Havu and Glenner
|
|
gptkbp:discoveredIn
|
1966
|
|
gptkbp:EC_number
|
3.4.14.5
|
|
gptkbp:Entrez_Gene_ID
|
1803
ENSG00000197635
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
intestine
immune cells
|
|
gptkbp:family
|
peptidase S9 family
|
|
gptkbp:fullName
|
gptkb:Dipeptidyl_peptidase-4
|
|
gptkbp:function
|
regulates glucose metabolism
cleaves dipeptides from polypeptides
involved in immune regulation
|
|
gptkbp:gene
|
gptkb:DPP4
|
|
gptkbp:GO_term
|
GO:0008239
|
|
gptkbp:HGNC_ID
|
HGNC:3009
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DPP4
|
|
gptkbp:inhibitedBy
|
gptkb:alogliptin
gptkb:sitagliptin
gptkb:saxagliptin
gptkb:vildagliptin
|
|
gptkbp:locatedOnChromosome
|
gptkb:2q24.2
chromosome 2q24.2
|
|
gptkbp:location
|
gptkb:cell_membrane
soluble form in plasma
|
|
gptkbp:molecularWeight
|
88 kDa
|
|
gptkbp:OMIM
|
102720
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Dpp4
rat Dpp4
|
|
gptkbp:otherName
|
gptkb:CD26
|
|
gptkbp:PDB
|
gptkb:1ORV
4A5S
4FFW
|
|
gptkbp:receptorFor
|
gptkb:MERS-CoV
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:GLP-1
gptkb:GIP
|
|
gptkbp:UniProtID
|
gptkb:P27487
|
|
gptkbp:bfsParent
|
gptkb:DPP-4_enzyme
|
|
gptkbp:bfsLayer
|
7
|