|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
Ser630
Asp708
His740
|
|
gptkbp:alternativeName
|
gptkb:CD26
DPP-4
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
|
|
gptkbp:discoveredIn
|
1966
|
|
gptkbp:EC_number
|
3.4.14.5
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
intestine
immune cells
|
|
gptkbp:function
|
cleaves dipeptides from polypeptides
regulates incretin hormones
|
|
gptkbp:gene
|
gptkb:DPP4
|
|
gptkbp:glycoprotein
|
true
|
|
gptkbp:inhibitedBy
|
gptkb:alogliptin
gptkb:sitagliptin
gptkb:saxagliptin
gptkb:vildagliptin
linagliptin
|
|
gptkbp:locatedOnChromosome
|
gptkb:2q24.2
|
|
gptkbp:location
|
cell surface
soluble form in plasma
|
|
gptkbp:molecularWeight
|
110 kDa
|
|
gptkbp:OMIM
|
102720
|
|
gptkbp:PDB
|
gptkb:1ORV
|
|
gptkbp:postTranslationalModification
|
gptkb:N-glycosylation
phosphorylation
|
|
gptkbp:receptorFor
|
gptkb:MERS-CoV
|
|
gptkbp:role
|
tumor biology
glucose metabolism
immune regulation
fibrosis
viral entry
T-cell activation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:GLP-1
gptkb:GIP
chemokines
neuropeptides
|
|
gptkbp:target
|
gptkb:DPP-4_inhibitors
|
|
gptkbp:transmembraneDomains
|
true
|
|
gptkbp:UniProtID
|
gptkb:P27487
|
|
gptkbp:bfsParent
|
gptkb:DPP-4_enzyme
gptkb:Dipeptidyl_peptidase
|
|
gptkbp:bfsLayer
|
8
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
Dipeptidyl peptidase-4
|