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gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:ADA
adenosine aminohydrolase
|
|
gptkbp:associatedWith
|
leukemia
tuberculosis
autoimmune diseases
immunodeficiency
|
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gptkbp:CASNumber
|
9026-93-1
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gptkbp:catalyzes
|
deamination of adenosine to inosine
|
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gptkbp:clinical_use
|
diagnosis of tuberculosis (pleural fluid ADA test)
marker for immune function
|
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gptkbp:cofactor
|
zinc
|
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gptkbp:deficiencyCauses
|
gptkb:severe_combined_immunodeficiency_(SCID)
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gptkbp:discoveredBy
|
John H. Kornberg
|
|
gptkbp:discoveredIn
|
1957
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gptkbp:EC_number
|
3.5.4.4
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:placenta
gptkb:thymus
liver
spleen
intestine
erythrocytes
lymphocytes
|
|
gptkbp:family
|
aminohydrolase family
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
humans
plants
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gptkbp:gene
|
gptkb:ADA
|
|
gptkbp:GO_term
|
GO:0004000
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
adenosine deaminase
|
|
gptkbp:inhibitedBy
|
gptkb:pentostatin
EHNA
|
|
gptkbp:locatedOnChromosome
|
20q13.12
|
|
gptkbp:molecularWeight
|
about 41 kDa
|
|
gptkbp:OMIM
|
608958
|
|
gptkbp:optimum_pH
|
37°C
7.0-7.5
|
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gptkbp:PDB
|
1ADD
|
|
gptkbp:product
|
ammonia
inosine
2'-deoxyinosine
|
|
gptkbp:structure
|
monomeric
|
|
gptkbp:substrate
|
gptkb:adenosine
2'-deoxyadenosine
|
|
gptkbp:UniProtID
|
P00813
|
|
gptkbp:used_in
|
gene therapy
enzyme replacement therapy
|
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gptkbp:bfsParent
|
gptkb:CHEBI:36208
|
|
gptkbp:bfsLayer
|
6
|