|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:CD26
|
|
gptkbp:cleavage
|
X-Pro or X-Ala dipeptides
|
|
gptkbp:cofactor
|
none required
|
|
gptkbp:discoveredIn
|
1966
|
|
gptkbp:EC_number
|
3.4.14.5
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
intestine
immune cells
|
|
gptkbp:fullName
|
gptkb:Dipeptidyl_peptidase-4
|
|
gptkbp:function
|
inactivates incretin hormones
cleaves dipeptides from the N-terminus of polypeptides
|
|
gptkbp:gene
|
gptkb:DPP4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DPP-4 enzyme
|
|
gptkbp:inhibitedBy
|
gptkb:alogliptin
gptkb:DPP-4_inhibitors
gptkb:sitagliptin
gptkb:saxagliptin
gptkb:vildagliptin
|
|
gptkbp:locatedOnChromosome
|
gptkb:2q24.2
|
|
gptkbp:location
|
cell surface
soluble form in plasma
|
|
gptkbp:molecularWeight
|
110 kDa
|
|
gptkbp:OMIM
|
102720
|
|
gptkbp:organism
|
gptkb:human
mammals
|
|
gptkbp:PDB
|
gptkb:1ORV
|
|
gptkbp:proteinFamily
|
gptkb:serine_protease
|
|
gptkbp:role
|
gptkb:type_2_diabetes
immune regulation
|
|
gptkbp:roleInCancer
|
biomarker
potential therapeutic target
|
|
gptkbp:roleInImmunity
|
T-cell activation
cytokine regulation
|
|
gptkbp:roleInTherapy
|
target for antidiabetic drugs
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:GLP-1
gptkb:neuropeptide_Y
gptkb:substance_P
gptkb:GIP
|
|
gptkbp:UniProtID
|
gptkb:P27487
|
|
gptkbp:bfsParent
|
gptkb:insulin
|
|
gptkbp:bfsLayer
|
6
|