|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Binding_immunoglobulin_protein
gptkb:GRP78
|
|
gptkbp:component
|
endoplasmic reticulum lumen
|
|
gptkbp:discoveredBy
|
gptkb:Kazutoshi_Mori
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:encodedBy
|
HSPA5 gene
|
|
gptkbp:Entrez_Gene_ID
|
3309
|
|
gptkbp:family
|
gptkb:HSP70_family
|
|
gptkbp:function
|
protein folding
unfolded protein response
ATP binding
protein binding
molecular chaperone
|
|
gptkbp:GOProcess
|
response to unfolded protein
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BiP protein
|
|
gptkbp:interactsWith
|
gptkb:ATF6
gptkb:IRE1
gptkb:PERK
misfolded proteins
|
|
gptkbp:involvedIn
|
gptkb:ER-associated_degradation_(ERAD)
protein quality control
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:marking
|
ER stress
|
|
gptkbp:molecularWeight
|
78 kDa
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Saccharomyces cerevisiae Kar2p
|
|
gptkbp:PDB
|
gptkb:5E84
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
ER stress response
|
|
gptkbp:requires
|
cell survival under stress
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
gptkb:Reactome
gptkb:KEGG
|
|
gptkbp:sequence
|
654 amino acids
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:structure
|
C-terminal substrate-binding domain
N-terminal ATPase domain
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:UniProtID
|
P11021
|
|
gptkbp:bfsParent
|
gptkb:Bip_(gene)
|
|
gptkbp:bfsLayer
|
6
|