Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
Heat shock protein 70 family
|
| gptkbp:co-chaperone |
BAG family proteins
nucleotide exchange factors HSP40 family |
| gptkbp:conservedIn |
ATPase domain
substrate-binding domain |
| gptkbp:discoveredBy |
gptkb:Ferruccio_Ritossa
|
| gptkbp:discoveredIn |
1962
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
protein folding
assists in protein transport across membranes molecular chaperone prevention of protein aggregation |
| gptkbp:GO_term |
gptkb:GO:0006457_(protein_folding)
GO:0006950 (response to stress) GO:0031072 (heat shock protein binding) |
| https://www.w3.org/2000/01/rdf-schema#label |
HSP70 family
|
| gptkbp:inducedBy |
heat shock
cellular stress |
| gptkbp:inhibitedBy |
gptkb:VER-155008
PES (2-phenylethynesulfonamide) |
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:nucleus chloroplasts mitochondria cytosol |
| gptkbp:member |
gptkb:HSPA12A
gptkb:HSPA12B gptkb:HSPA13 gptkb:HSPA14 gptkb:HSPA1L gptkb:HSPA2 gptkb:HSPA6 gptkb:HSPA9 gptkb:HSPA1A gptkb:HSPA1B gptkb:HSPA8 gptkb:HSPA5 |
| gptkbp:molecularWeight |
approximately 70 kDa
|
| gptkbp:role |
gptkb:cancer
neurodegenerative diseases immune response protein quality control apoptosis regulation cellular stress response protein homeostasis disease processes |
| gptkbp:structure |
C-terminal substrate-binding domain
N-terminal ATPase domain |
| gptkbp:bfsParent |
gptkb:P25445
gptkb:BiP_protein |
| gptkbp:bfsLayer |
7
|