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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
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Heat shock protein 70 family
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gptkbp:co-chaperone
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BAG family proteins
nucleotide exchange factors
HSP40 family
|
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gptkbp:conservedIn
|
ATPase domain
substrate-binding domain
|
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gptkbp:discoveredBy
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gptkb:Ferruccio_Ritossa
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gptkbp:discoveredIn
|
1962
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gptkbp:foundIn
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gptkb:Bacteria
archaea
eukaryotes
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gptkbp:function
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gptkb:molecular_chaperone
protein folding
assists in protein transport across membranes
prevention of protein aggregation
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gptkbp:GO_term
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gptkb:GO:0006457_(protein_folding)
GO:0006950 (response to stress)
GO:0031072 (heat shock protein binding)
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gptkbp:inducedBy
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heat shock
cellular stress
|
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gptkbp:inhibitedBy
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gptkb:VER-155008
PES (2-phenylethynesulfonamide)
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gptkbp:locale
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gptkb:endoplasmic_reticulum
gptkb:nucleus
chloroplasts
mitochondria
cytosol
|
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gptkbp:member
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gptkb:HSPA12A
gptkb:HSPA12B
gptkb:HSPA13
gptkb:HSPA14
gptkb:HSPA1L
gptkb:HSPA2
gptkb:HSPA6
gptkb:HSPA9
gptkb:HSPA1A
gptkb:HSPA1B
gptkb:HSPA8
gptkb:HSPA5
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:role
|
gptkb:cancer
gptkb:immune_response
gptkb:cellular_stress_response
neurodegenerative diseases
protein quality control
apoptosis regulation
protein homeostasis
disease processes
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gptkbp:structure
|
C-terminal substrate-binding domain
N-terminal ATPase domain
|
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gptkbp:bfsParent
|
gptkb:P25445
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gptkbp:bfsLayer
|
7
|
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https://www.w3.org/2000/01/rdf-schema#label
|
HSP70 family
|