Brain-derived neurotrophic factor

URI: https://gptkb.org/entity/Brain-derived_neurotrophic_factor
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:BDNF
gptkbp:associatedWith gptkb:depression
memory
learning
neuroplasticity
gptkbp:discoveredBy gptkb:Yves-Alain_Barde
gptkbp:discoveredIn 1982
gptkbp:encodedBy gptkb:BDNF_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000176697
627
gptkbp:expressedIn gptkb:spinal_cord
gptkb:cerebellum
gptkb:cortex
hippocampus
amygdala
gptkbp:foundIn brain
peripheral nervous system
gptkbp:function supports survival of existing neurons
encourages growth and differentiation of new neurons and synapses
gptkbp:HGNC_ID 1033
https://www.w3.org/2000/01/rdf-schema#label Brain-derived neurotrophic factor
gptkbp:locatedOnChromosome gptkb:chromosome_11_(human)
gptkbp:memberOf neurotrophin family
gptkbp:molecularWeight ~27 kDa
gptkbp:mutationAssociatedWith obesity
neurodevelopmental disorders
psychiatric disorders
gptkbp:OMIM 113505
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
right
gptkbp:recipient gptkb:p75NTR
gptkb:TrkB
gptkbp:regulates upregulated by exercise
affected by stress
downregulated in Alzheimer's disease
gptkbp:relatedTo gptkb:nerve_growth_factor
gptkb:neurotrophin-3
gptkb:neurotrophin-4
gptkbp:role gptkb:synaptic_plasticity
gptkb:long-term_potentiation
axon growth
dendrite growth
energy metabolism
appetite regulation
gptkbp:sequence human BDNF precursor: 247 amino acids
gptkbp:therapeuticPotential neurodegenerative diseases
psychiatric disorders
gptkbp:UniProtID gptkb:P23560
gptkbp:bfsParent gptkb:BDNF
gptkbp:bfsLayer 7