finasteride

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:drug
5α-reductase inhibitor
gptkbp:approvedBy gptkb:FDA
1992
gptkbp:ATCCode G04CB01
gptkbp:availableOn generic medication
gptkbp:bioavailability 63%
gptkbp:brand gptkb:Propecia
gptkb:Proscar
gptkbp:CASNumber 98319-26-7
gptkbp:chemicalClass steroid-like
gptkbp:chemicalFormula C23H36N2O2
gptkbp:contraindication children
pregnancy
gptkbp:developedBy gptkb:Merck_&_Co.
gptkbp:discoveredBy gptkb:Merck_&_Co.
gptkbp:eliminationHalfLife 4.8-7.1 hours
gptkbp:excretion urine
feces
https://www.w3.org/2000/01/rdf-schema#label finasteride
gptkbp:interactsWith gptkb:dihydrotestosterone
gptkb:dutasteride
testosterone
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits type II 5α-reductase
gptkbp:metabolism liver
gptkbp:metabolites inactive
gptkbp:molecularWeight 372.549 g/mol
gptkbp:notRecommendedFor gptkb:women
children
gptkbp:patentExpired 2013
gptkbp:pregnancyCategory D
X
X (contraindicated)
gptkbp:pregnancyWarning may cause birth defects in male fetus
gptkbp:prescribes enlarged prostate
androgenetic alopecia
gptkbp:prescriptionStatus Rx-only
gptkbp:proteinBinding 90%
gptkbp:PubChem_CID gptkb:DB01216
gptkbp:reduces dihydrotestosterone (DHT) levels
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:depression
decreased libido
gynecomastia
erectile dysfunction
gptkbp:synonym gptkb:MK-906
gptkb:N-(1,1-dimethylethyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide
gptkbp:usedFor gptkb:benign_prostatic_hyperplasia
male pattern baldness
gptkbp:WHOModelListOfEssentialMedicines no
gptkbp:bfsParent gptkb:Propecia
gptkb:Proscar
gptkbp:bfsLayer 5