|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:AIS
AR
DHTR
|
|
gptkbp:associatedWith
|
gptkb:androgen_insensitivity_syndrome
gptkb:spinal_and_bulbar_muscular_atrophy
prostate cancer
|
|
gptkbp:biologicalProcess
|
transcription regulation
DNA binding
steroid binding
|
|
gptkbp:discoveredBy
|
genetic studies of androgen insensitivity
|
|
gptkbp:encodes
|
gptkb:androgen_receptor
|
|
gptkbp:Entrez_Gene_ID
|
367
ENSG00000169083
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:prostate
gptkb:testis
brain
|
|
gptkbp:function
|
transcription factor
nuclear receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:644
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NR3C4
|
|
gptkbp:interactsWith
|
gptkb:androgens
gptkb:dihydrotestosterone
testosterone
coactivators
corepressors
|
|
gptkbp:length
|
8 exons
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xq11-12
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Kennedy's_disease
androgen insensitivity
prostate cancer progression
|
|
gptkbp:OMIM
|
313700
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Ar gene
|
|
gptkbp:product
|
gptkb:androgen_receptor
|
|
gptkbp:proteinFamily
|
DNA-binding domain
N-terminal domain
ligand-binding domain
hinge region
|
|
gptkbp:regulates
|
phosphorylation
sumoylation
ubiquitination
male sexual development
prostate growth
muscle mass
hormone-dependent
|
|
gptkbp:significance
|
marker for androgen insensitivity
target for prostate cancer therapy
|
|
gptkbp:UniProtID
|
P10275
|
|
gptkbp:bfsParent
|
gptkb:P06493
|
|
gptkbp:bfsLayer
|
6
|