|
gptkbp:instanceOf
|
gptkb:drug
potassium-sparing diuretic
steroidal antimineralocorticoid
|
|
gptkbp:ATCCode
|
C03DA01
|
|
gptkbp:bioavailability
|
60-90%
|
|
gptkbp:brand
|
gptkb:Aldactone
gptkb:Carospir
|
|
gptkbp:CASNumber
|
52-01-7
|
|
gptkbp:contraindication
|
renal failure
Addison's disease
hyperkalemia
|
|
gptkbp:discoveredBy
|
gptkb:G._D._Searle_&_Company
|
|
gptkbp:eliminationHalfLife
|
1.4 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:hasMolecularFormula
|
C24H32O4S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
spironolactone
|
|
gptkbp:introducedIn
|
1959
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
androgen receptor antagonist
aldosterone receptor antagonist
progestogen receptor agonist
|
|
gptkbp:meltingPoint
|
134-135°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
B3 (Australia)
|
|
gptkbp:proteinBinding
|
90%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1391
5833
5629
DB00421
|
|
gptkbp:riskFactor
|
breast tenderness
rash
impotence
electrolyte imbalance
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
drowsiness
gynecomastia
gastrointestinal upset
hyperkalemia
menstrual irregularities
|
|
gptkbp:solubility
|
practically insoluble in water
|
|
gptkbp:synonym
|
gptkb:7α-acetylthiospirolactone
NSC-150408
|
|
gptkbp:UNII
|
27O7W4T232
|
|
gptkbp:usedFor
|
gptkb:polycystic_ovary_syndrome
heart failure
edema
hypertension
acne
hirsutism
primary hyperaldosteronism
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:trimethoprim-sulfamethoxazole
|
|
gptkbp:bfsLayer
|
6
|