|
gptkbp:instanceOf
|
transcription factor
|
|
gptkbp:abbreviation
|
gptkb:AP-1
|
|
gptkbp:activatedBy
|
cytokines
growth factors
phorbol esters
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:composedOf
|
gptkb:Fos_family_proteins
gptkb:Jun_family_proteins
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:domain
|
gptkb:basic_leucine_zipper_(bZIP)
|
|
gptkbp:encodedBy
|
gptkb:FOS_gene
gptkb:JUN_gene
|
|
gptkbp:form
|
heterodimers
homodimers
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:hasRole
|
gptkb:cancer
development
wound healing
neurodegenerative diseases
autoimmune diseases
inflammatory diseases
stress response
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Activator Protein 1
|
|
gptkbp:involvedIn
|
apoptosis
cell proliferation
differentiation
oncogenesis
|
|
gptkbp:modulatedBy
|
gptkb:MAPK_pathway
gptkb:ERK_pathway
gptkb:JNK_pathway
p38 pathway
|
|
gptkbp:recognizesMotif
|
gptkb:TRE_(TPA_response_element)
|
|
gptkbp:regulates
|
cell survival
gene expression
inflammation
metastasis
immune response
cell cycle
|
|
gptkbp:subunit
|
gptkb:c-Jun
gptkb:FosB
gptkb:Fra-1
gptkb:Fra-2
gptkb:JunD
gptkb:c-Fos
gptkb:JunB
|
|
gptkbp:target
|
therapeutic research
pharmacological inhibitors
|
|
gptkbp:bfsParent
|
gptkb:AP1
|
|
gptkbp:bfsLayer
|
7
|