|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:BMAL1
Bmal
MOP3
PASD3
bHLHe5
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes_mellitus
gptkb:metabolic_syndrome
sleep disorders
|
|
gptkbp:biologicalProcess
|
cell cycle regulation
regulation of transcription
circadian rhythm
DNA binding
transcriptional activator activity
metabolic process
response to light stimulus
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:chromosomeArm
|
gptkb:11p15.3
|
|
gptkbp:discoveredBy
|
Ueda HR et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
Aryl hydrocarbon receptor nuclear translocator-like protein 1
|
|
gptkbp:Entrez_Gene_ID
|
406
ENSG00000111790
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
liver
pancreas
|
|
gptkbp:formsHeterodimerWith
|
gptkb:NPAS2
gptkb:CLOCK
|
|
gptkbp:function
|
transcription factor
core component of circadian clock
|
|
gptkbp:HGNC_ID
|
HGNC:701
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ARNTL
|
|
gptkbp:interactsWith
|
gptkb:SIRT1
gptkb:CBP
gptkb:NPAS2
gptkb:CLOCK
gptkb:CRY1
gptkb:CRY2
gptkb:PER1
gptkb:PER2
gptkb:REV-ERBα
gptkb:p300
RORα
|
|
gptkbp:locatedOnChromosome
|
11
|
|
gptkbp:OMIM
|
604781
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Arntl
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:PAS
Transactivation domain
bHLH
|
|
gptkbp:regulates
|
gptkb:CRY1
gptkb:CRY2
gptkb:PER1
gptkb:PER2
gptkb:DBP
regulated by glucocorticoids
NR1D1
RORs
regulated by REV-ERBα
regulated by RORα
regulated by SIRT1
regulated by circadian rhythm
regulated by feeding
regulated by light
|
|
gptkbp:UniProtID
|
O00327
|
|
gptkbp:bfsParent
|
gptkb:Circadian_Locomotor_Output_Cycles_Kaput
gptkb:BHLHE2
gptkb:NPAS2
gptkb:BMAL1
gptkb:PER2
|
|
gptkbp:bfsLayer
|
8
|