|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:alternativeName
|
NR1D1
Nuclear receptor subfamily 1 group D member 1
Orphan nuclear receptor
|
|
gptkbp:associatedWith
|
sleep disorders
inflammation
metabolic regulation
|
|
gptkbp:binds
|
RORE DNA elements
|
|
gptkbp:cofactor
|
gptkb:HDAC3
gptkb:NCoR
|
|
gptkbp:discoveredBy
|
Ueda et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
NR1D1 gene
|
|
gptkbp:Entrez_Gene_ID
|
9572
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
adipose tissue
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of circadian rhythm
transcriptional repressor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
REV-ERBα
|
|
gptkbp:inhibitedBy
|
BMAL1 transcription
|
|
gptkbp:length
|
614 amino acids
|
|
gptkbp:ligand
|
hemoglobin
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
chromosome 17q11.2 (human)
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:orthologIn
|
REV-ERBα (mouse)
|
|
gptkbp:PDB
|
3N00
|
|
gptkbp:phosphorylates
|
Ser59
Ser48
Ser55
|
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gptkbp:regulates
|
gptkb:BMAL1
lipid metabolism
glucose metabolism
autophagy
inflammatory response
mitochondrial biogenesis
sleep-wake cycle
energy homeostasis
clock genes
|
|
gptkbp:target
|
gptkb:SR9011
synthetic agonists
SR9009
|
|
gptkbp:UniProtID
|
P20393
|
|
gptkbp:bfsParent
|
gptkb:SR_90000
gptkb:SR_90001
gptkb:SR_90002
gptkb:SR_90003
gptkb:SR_90005
|
|
gptkbp:bfsLayer
|
8
|