|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
PHLL
PHLL1
cryptochrome 1
|
|
gptkbp:associatedWith
|
delayed sleep phase disorder
|
|
gptkbp:chromosomeArm
|
12q23.3
|
|
gptkbp:discoveredBy
|
Ahmad and Cashmore
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
FAD-binding domain
photolyase homology region
|
|
gptkbp:encodes
|
cryptochrome-1 protein
|
|
gptkbp:Entrez_Gene_ID
|
1407
ENSG00000008405
|
|
gptkbp:expressedIn
|
brain
retina
liver
|
|
gptkbp:fullName
|
cryptochrome circadian regulator 1
|
|
gptkbp:function
|
regulation of circadian rhythm
transcriptional repressor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
2386
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CRY1
|
|
gptkbp:inhibitedBy
|
CLOCK-BMAL1 complex
|
|
gptkbp:interactsWith
|
gptkb:BMAL1
gptkb:CLOCK
gptkb:PER1
gptkb:PER2
|
|
gptkbp:length
|
586 amino acids
|
|
gptkbp:locatedOnChromosome
|
12
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:mutationAssociatedWith
|
sleep disorders
|
|
gptkbp:OMIM
|
601933
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInDrosophila
|
cry
|
|
gptkbp:orthologInMouse
|
Cry1
|
|
gptkbp:regulates
|
transcription
phosphorylation
ubiquitination
post-translational modifications
proteasomal degradation
circadian clock
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q16526
|
|
gptkbp:bfsParent
|
gptkb:Suprachiasmatic_nucleus
|
|
gptkbp:bfsLayer
|
7
|