|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
Period homolog 2
circadian clock protein PERIOD 2
hPER2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
circadian rhythm
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
PER2 protein
|
|
gptkbp:Entrez_Gene_ID
|
8864
|
|
gptkbp:expressedIn
|
brain
heart
liver
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
period circadian regulator 2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:8841
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PER2
|
|
gptkbp:interactsWith
|
gptkb:PER3
gptkb:CRY1
gptkb:CRY2
gptkb:PER1
CK1ε
|
|
gptkbp:involvedIn
|
negative feedback loop of circadian clock
|
|
gptkbp:length
|
1255 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:human_chromosome_2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:depression
cancer susceptibility
familial advanced sleep phase syndrome
|
|
gptkbp:OMIM
|
603426
|
|
gptkbp:orthologInFruitFly
|
per
|
|
gptkbp:orthologInMouse
|
Per2
|
|
gptkbp:orthologInZebrafish
|
per2
|
|
gptkbp:phosphorylates
|
CK1δ
CK1ε
|
|
gptkbp:proteinFamily
|
PAS domain
nuclear export signal
nuclear localization signal
PAC domain
|
|
gptkbp:regulates
|
gptkb:ARNTL
gptkb:NPAS2
gptkb:BMAL1
gptkb:CLOCK
gene expression
transcription
metabolism
cell cycle
sleep-wake cycle
hormone secretion
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
O15055
|
|
gptkbp:bfsParent
|
gptkb:Suprachiasmatic_nucleus
|
|
gptkbp:bfsLayer
|
7
|