|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:ARNTL
Brain and Muscle ARNT-Like 1
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:domain
|
bHLH-PAS domain
|
|
gptkbp:encodedBy
|
ARNTL gene
|
|
gptkbp:Entrez_Gene_ID
|
406
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
|
|
gptkbp:formsComplexWith
|
gptkb:NPAS2
gptkb:CLOCK
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcription factor
core circadian clock component
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BMAL1
|
|
gptkbp:interactsWith
|
PER proteins
CRY proteins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(human)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:metabolic_syndrome
aging
sleep disorders
|
|
gptkbp:OMIM
|
602550
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
Drosophila melanogaster (as CYCLE)
|
|
gptkbp:phosphorylates
|
CK1δ
CK1ε
|
|
gptkbp:regulates
|
gptkb:CRY1
gptkb:CRY2
gptkb:PER1
gptkb:PER2
transcription
lipid metabolism
immune response
cell cycle
oxidative stress response
insulin secretion
glucose homeostasis
circadian rhythm
metabolic processes
clock-controlled genes
|
|
gptkbp:requires
|
circadian rhythm generation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
O00327
|
|
gptkbp:bfsParent
|
gptkb:bHLH-PAS
gptkb:Suprachiasmatic_nucleus
|
|
gptkbp:bfsLayer
|
7
|