Familial adenomatous polyposis

URI: https://gptkb.org/entity/Familial_adenomatous_polyposis
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf genetic disorder
hereditary cancer syndrome
gptkbp:affectsOrgan colon
rectum
gptkbp:cause gptkb:hepatoblastoma
gptkb:cancer
congenital hypertrophy of the retinal pigment epithelium
desmoid tumors
duodenal polyps
epidermoid cysts
osteomas
gptkbp:characterizedBy hundreds to thousands of colorectal polyps
gptkbp:complication gptkb:hepatoblastoma
gptkb:cancer
colorectal cancer
congenital hypertrophy of the retinal pigment epithelium
desmoid tumors
duodenal cancer
epidermoid cysts
gastric polyps
osteomas
gptkbp:diagnosedBy genetic testing
colonoscopy
gptkbp:firstDescribed gptkb:Samuel_Wilks
gptkbp:guidanceSystem gptkb:NCCN_Guidelines
gptkb:American_Cancer_Society
https://www.w3.org/2000/01/rdf-schema#label Familial adenomatous polyposis
gptkbp:ICD-10_code Q85.8
gptkbp:inheritance autosomal dominant
gptkbp:MeSH_ID D004047
gptkbp:mutationAssociatedWith gptkb:APC_gene
gptkbp:namedAfter adenomatous polyps
gptkbp:OMIM 175100
gptkbp:onset adolescence
gptkbp:prevalence 1 in 7,000 to 1 in 22,000 live births
gptkbp:riskFactor colorectal cancer
gptkbp:subspecies gptkb:Gardner_syndrome
gptkb:Turcot_syndrome
gptkb:attenuated_familial_adenomatous_polyposis
gptkbp:symptom gptkb:anemia
diarrhea
abdominal pain
weight loss
rectal bleeding
gptkbp:synonym gptkb:FAP
gptkbp:treatment colectomy
chemoprevention
endoscopic polypectomy
gptkbp:bfsParent gptkb:chromosome_5
gptkbp:bfsLayer 5