|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:AIK
ARK1
Aurora 2
STK6
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
prostate cancer
|
|
gptkbp:discoveredBy
|
Kimura et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:Entrez_Gene_ID
|
6790
ENSG00000087586
|
|
gptkbp:expressedIn
|
gptkb:testis
gptkb:thymus
fetal liver
|
|
gptkbp:fullName
|
Aurora kinase A
|
|
gptkbp:function
|
serine/threonine-protein kinase
spindle assembly
regulation of mitosis
centrosome maturation
|
|
gptkbp:GO_term
|
GO:0007067
GO:0004693
GO:0000287
|
|
gptkbp:HGNC_ID
|
11393
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AURKA
|
|
gptkbp:inhibitedBy
|
Alisertib
MLN8054
VX-680
|
|
gptkbp:locatedOnChromosome
|
gptkb:20q13.2
|
|
gptkbp:location
|
centrosome
spindle microtubules
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
aneuploidy
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Aurora kinase A (mouse)
Aurora kinase A (rat)
|
|
gptkbp:PDB
|
1OL5
4CEG
5L8K
|
|
gptkbp:phosphorylates
|
gptkb:PLK1
gptkb:p53
TPX2
|
|
gptkbp:regulates
|
cell cycle
cytokinesis
chromosome segregation
|
|
gptkbp:UniProtID
|
O14965
|
|
gptkbp:bfsParent
|
gptkb:APC_gene
gptkb:20q13.2
|
|
gptkbp:bfsLayer
|
7
|