Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:3-hydroxy-3-methylglutaryl-CoA_reductase
|
| gptkbp:catalyzes |
conversion of HMG-CoA to mevalonate
|
| gptkbp:cofactor |
NADPH
|
| gptkbp:discoveredBy |
gptkb:Konrad_Bloch
|
| gptkbp:EC_number |
1.1.1.34
|
| gptkbp:foundIn |
endoplasmic reticulum membrane
|
| gptkbp:gene |
gptkb:HMGCR
|
| gptkbp:GO_term |
GO:0004420
|
| https://www.w3.org/2000/01/rdf-schema#label |
HMG-CoA reductase
|
| gptkbp:inhibitedBy |
statins
|
| gptkbp:involvedIn |
gptkb:mevalonate_pathway
cholesterol biosynthesis |
| gptkbp:locale |
integral membrane protein
|
| gptkbp:molecularWeight |
~97 kDa
|
| gptkbp:organism |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:product |
gptkb:mevalonate
|
| gptkbp:regulates |
regulated by phosphorylation
feedback inhibition by cholesterol regulated by SREBP |
| gptkbp:significance |
target of cholesterol-lowering drugs
|
| gptkbp:structure |
tetramer
|
| gptkbp:substrate |
gptkb:HMG-CoA
|
| gptkbp:UniProtID |
P04035
|
| gptkbp:bfsParent |
gptkb:HMG
gptkb:AMPK |
| gptkbp:bfsLayer |
6
|