|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:insulin
citrate
|
|
gptkbp:alternativeName
|
gptkb:ACC
acetyl coenzyme A carboxylase
|
|
gptkbp:catalyzes
|
carboxylation of acetyl-CoA to malonyl-CoA
|
|
gptkbp:cofactor
|
gptkb:biotin
|
|
gptkbp:EC_number
|
6.4.1.2
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
mammary gland
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
|
|
gptkbp:gene
|
gptkb:ACACA
gptkb:ACACB
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
acetyl-CoA carboxylase
|
|
gptkbp:inhibitedBy
|
gptkb:AMP-activated_protein_kinase
gptkb:glucagon
epinephrine
long-chain fatty acids
fatty acyl-CoA
|
|
gptkbp:involvedIn
|
fatty acid biosynthesis
|
|
gptkbp:locale
|
cytosol (ACC1)
mitochondria (ACC2)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12q24.1_(ACACB)
gptkb:chromosome_17q12_(ACACA)
|
|
gptkbp:molecularWeight
|
~265 kDa (monomer)
|
|
gptkbp:mutationAssociatedWith
|
metabolic disorders
|
|
gptkbp:phosphorylates
|
Ser221 (human ACC2)
Ser79 (human ACC1)
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
plants
|
|
gptkbp:regulates
|
citrate
phosphorylation
dephosphorylation
palmitoyl-CoA
|
|
gptkbp:requires
|
lipogenesis
|
|
gptkbp:significance
|
target for cancer therapy
target for type 2 diabetes therapy
|
|
gptkbp:structure
|
multidomain protein
|
|
gptkbp:subunit
|
biotin carboxyl carrier protein
biotin carboxylase
carboxyltransferase
|
|
gptkbp:target
|
herbicides
anti-obesity drugs
|
|
gptkbp:type
|
acetyl-CoA + HCO3- + ATP → malonyl-CoA + ADP + Pi
|
|
gptkbp:bfsParent
|
gptkb:BCCP
gptkb:AMPK
|
|
gptkbp:bfsLayer
|
6
|