AMP-activated protein kinase (AMPK)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	gptkb:AMP gptkb:ADP
gptkbp:composedOf	alpha subunit beta subunit gamma subunit
gptkbp:discoveredBy	gptkb:D._Grahame_Hardie
gptkbp:discoveredIn	1980s
gptkbp:encodedBy	gptkb:PRKAA1 gptkb:PRKAA2 gptkb:PRKAB1 gptkb:PRKAB2 gptkb:PRKAG1 gptkb:PRKAG2 gptkb:PRKAG3
gptkbp:foundIn	eukaryotes
gptkbp:function	cellular energy sensor
https://www.w3.org/2000/01/rdf-schema#label	AMP-activated protein kinase (AMPK)
gptkbp:inhibitedBy	gptkb:ATP gptkb:mTOR_pathway lipogenesis
gptkbp:involvedIn	gptkb:type_2_diabetes obesity cancer metabolism exercise response metabolic stress response fasting response
gptkbp:locale	gptkb:nucleus gptkb:cytoplasm
gptkbp:phosphorylates	gptkb:HMG-CoA_reductase gptkb:TSC2 gptkb:bird gptkb:acetyl-CoA_carboxylase
gptkbp:promotion	glucose uptake autophagy fatty acid oxidation
gptkbp:regulates	lipid metabolism glucose uptake protein synthesis autophagy fatty acid oxidation
gptkbp:target	gptkb:AICAR gptkb:metformin gptkb:thiazolidinediones berberine resveratrol salicylate
gptkbp:bfsParent	gptkb:D._Grahame_Hardie gptkb:AMP-activated_protein_kinase_pathway
gptkbp:bfsLayer	7