|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:insulin
growth factors
|
|
gptkbp:alternativeName
|
gptkb:PKB_alpha
RAC-PK alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:biologicalProcess
|
serine/threonine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Dario_Alessi
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:Entrez_Gene_ID
|
207
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:function
|
signal transduction
cell growth regulation
metabolism regulation
cell survival regulation
apoptosis inhibition
|
|
gptkbp:gene
|
gptkb:AKT1
|
|
gptkbp:HGNC_ID
|
391
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT-1
|
|
gptkbp:inhibitedBy
|
gptkb:Ipatasertib
gptkb:MK-2206
gptkb:Perifosine
|
|
gptkbp:length
|
480
|
|
gptkbp:locatedOnChromosome
|
14q32.33
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:OMIM
|
164730
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
AKT-1 (C. elegans)
Akt1 (mouse)
|
|
gptkbp:pathway
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:PDB
|
gptkb:1UNQ
4EJN
|
|
gptkbp:phosphorylates
|
Ser473
Thr308
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NM_005163
|
|
gptkbp:regulates
|
gptkb:GSK-3
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR
gptkb:p27_Kip1
|
|
gptkbp:UniProtID
|
gptkb:P31749
|
|
gptkbp:bfsParent
|
gptkb:C._elegans_DAF-16
|
|
gptkbp:bfsLayer
|
7
|