|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:menaquinone
gptkb:vitamin_A
Nutrient
|
|
gptkbp:absorbedBy
|
gptkb:small_intestine
|
|
gptkbp:absorptionEnhancedBy
|
dietary fat
|
|
gptkbp:administeredBy
|
injection
oral supplement
|
|
gptkbp:alsoKnownAs
|
gptkb:phylloquinone
gptkb:axerophthol
gptkb:retinol
gptkb:cholecalciferol
|
|
gptkbp:alternativeName
|
Vitamin
Vitamin_B3
retinoid
vitamin
vitamin_D3
vitamin_E
vitamin_K
vitamin_K1
vitamin_K2
|
|
gptkbp:approvedBy
|
gptkb:FDA
dietary supplements
|
|
gptkbp:approvedForUseBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
A11CA01
A11CC05
B02BA01
|
|
gptkbp:awardedNobelPrizeField
|
Physiology or Medicine
|
|
gptkbp:awardedNobelPrizeYear
|
1943
|
|
gptkbp:biosynthesized_from
|
plants
gut bacteria
7-dehydrocholesterol
|
|
gptkbp:cannotBeSynthesizedBy
|
Human body (in sufficient quantities)
|
|
gptkbp:CASNumber
|
84-80-0 (K1)
68-26-8
67-97-0
84-80-0
11032-49-8 (MK-7)
|
|
gptkbp:category
|
gptkb:vitamin_A
antioxidant
dietary supplement
nutritionist
over-the-counter medication
nutrients
fat-soluble vitamins
fat-soluble vitamin
coagulation factors
quinones
coenzymes
hormone precursor
|
|
gptkbp:chemicalFormula
|
C31H46O2 (for K1)
C20H30O
C27H44O
C31H46O2
C46H64O2 (for MK-7)
|
|
gptkbp:class
|
Fat-soluble vitamin
Water-soluble vitamin
|
|
gptkbp:coinedBy
|
gptkb:Casimir_Funk
|
|
gptkbp:color
|
yellow
|
|
gptkbp:contraindication
|
gptkb:hypercalcemia
anticoagulants
sarcoidosis
|
|
gptkbp:deficiencyCauses
|
gptkb:bone
gptkb:osteomalacia
gptkb:rickets
muscle weakness
bone pain
bleeding disorders
Diseases
immune deficiency
night blindness
xerophthalmia
arterial calcification
increased risk of bleeding
Health problems
|
|
gptkbp:discoveredBy
|
gptkb:Adolf_Windaus
gptkb:Henrik_Dam
gptkb:Elmer_McCollum
gptkb:Dam_Henrik
|
|
gptkbp:discoveredIn
|
1913
1929
1936
Early 20th century
|
|
gptkbp:enemyOf
|
gptkb:warfarin
|
|
gptkbp:etymology
|
Vital amine
|
|
gptkbp:excessCauses
|
gptkb:hypervitaminosis_A
Toxicity (in some cases)
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:fatSoluble
|
true
|
|
gptkbp:firstIsolatedFrom
|
alfalfa
|
|
gptkbp:form
|
vitamin D
|
|
gptkbp:foundIn
|
gptkb:meat
gptkb:cheese
gptkb:natto
broccoli
carrots
lettuce
sweet potatoes
dairy products
liver
egg yolk
kale
fortified foods
animal products
animal liver
fermented foods
green leafy vegetables
plant oils
fish liver oils
fermented soybeans
|
|
gptkbp:function
|
cardiovascular health
blood clotting
bone metabolism
|
|
gptkbp:halfLife
|
several days (MK-7)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
vitamin A
|
|
gptkbp:includes
|
gptkb:Vitamin_C
gptkb:vitamin_A
gptkb:Vitamin_E
gptkb:Vitamin_B1
gptkb:Vitamin_K
gptkb:Vitamin_A
gptkb:Vitamin_B7
gptkb:Vitamin_B9
gptkb:Vitamin_B12
Vitamin D
Vitamin B6
Vitamin B2
Vitamin B5
|
|
gptkbp:isAvailableAsSupplement
|
true
|
|
gptkbp:isEssentialNutrient
|
true
|
|
gptkbp:isMeasuredIn
|
gptkb:International_Units_(IU)
micrograms (mcg)
|
|
gptkbp:IUPACName
|
gptkb:2-methyl-3-phytyl-1,4-naphthoquinone_(K1)
gptkb:2-methyl-3-phytyl-1,4-naphthoquinone
gptkb:(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
gptkb:2-methyl-3-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-1,4-naphthoquinone_(MK-10)
|
|
gptkbp:legalStatus
|
OTC (over-the-counter)
|
|
gptkbp:meltingPoint
|
5-7°C
52°C (K1)
83–86 °C
|
|
gptkbp:MeSH_ID
|
gptkb:D014801
D014807
|
|
gptkbp:metabolism
|
gptkb:kidney
liver
|
|
gptkbp:molecularWeight
|
450.7 g/mol (K1)
286.45 g/mol
450.7 g/mol
649.0 g/mol (MK-7)
|
|
gptkbp:namedFor
|
gptkb:Henrik_Dam
|
|
gptkbp:nameOrigin
|
'Koagulation' (Danish for coagulation)
|
|
gptkbp:NobelPrizeYear
|
gptkb:Henrik_Dam
|
|
gptkbp:notSynthesizedBy
|
humans
|
|
gptkbp:obtainedFrom
|
gptkb:food
|
|
gptkbp:otherName
|
gptkb:menadione
gptkb:menaquinone
gptkb:phylloquinone
|
|
gptkbp:predecessor
|
gptkb:calcitriol
gptkb:beta-carotene
gptkb:calcifediol
|
|
gptkbp:producedBy
|
gptkb:skin
exposure to ultraviolet B (UVB) light
|
|
gptkbp:PubChem_CID
|
gptkb:CHEBI:33721
445354
5280795
CHEBI:28940
|
|
gptkbp:recommendedDailyIntake
|
90-120 mcg for adults
not established
|
|
gptkbp:regulates
|
gptkb:FDA
gptkb:EFSA
gptkb:coagulation_factors_II,_VII,_IX,_X
prothrombin synthesis
calcium deposition
calcium metabolism
phosphate metabolism
|
|
gptkbp:relatedTo
|
gptkb:beta-carotene
gptkb:vitamin_D2
gptkb:vitamin_A
gptkb:vitamin_K3
gptkb:ergocalciferol
retinal
retinoic acid
retinyl ester
|
|
gptkbp:requires
|
gptkb:DVD
cell growth
bone health
skin health
Human health
blood clotting
bone metabolism
immune system function
activation of matrix Gla-protein
activation of osteocalcin
Small amounts
|
|
gptkbp:role
|
gamma-carboxylation of glutamic acid residues
|
|
gptkbp:sideEffect
|
hypercalcemia (in overdose)
|
|
gptkbp:solubility
|
insoluble in water
fat
soluble in organic solvents
fat-soluble
|
|
gptkbp:storage
|
liver
|
|
gptkbp:subspecies
|
gptkb:vitamin_A
gptkb:menaquinone-4_(MK-4)
gptkb:menaquinone-7_(MK-7)
gptkb:menaquinone-9_(MK-9)
|
|
gptkbp:synthesisType
|
gut bacteria
|
|
gptkbp:syntheticForm
|
gptkb:menadione_(K3)
|
|
gptkbp:toxicity
|
rare (except K3)
|
|
gptkbp:transportation
|
gptkb:chylomicrons
|
|
gptkbp:type
|
gptkb:vitamin_A
gptkb:vitamin_K3
|
|
gptkbp:UNII
|
81G40H8B0T
1C6V77QF41
|
|
gptkbp:usedAs
|
dietary supplement
antidote for warfarin overdose
|
|
gptkbp:usedFor
|
supporting eye health
treating vitamin A deficiency
antidote to warfarin
supporting immune function
treating vitamin K deficiency
treatment of osteoporosis
treatment of vitamin D deficiency
prevention of rickets
|
|
gptkbp:usedIn
|
Dietary supplements
osteoporosis prevention
cardiovascular disease prevention
Fortified foods
|
|
gptkbp:bfsParent
|
gptkb:milk
|
|
gptkbp:bfsLayer
|
3
|