|
gptkbp:instanceOf
|
gptkb:drug
gptkb:anticoagulant
|
|
gptkbp:activeIngredient
|
gptkb:warfarin
|
|
gptkbp:affects
|
coagulation cascade
|
|
gptkbp:approvedBy
|
gptkb:FDA
1954
|
|
gptkbp:ATCCode
|
gptkb:B01AA03
|
|
gptkbp:brand
|
gptkb:warfarin
|
|
gptkbp:chemicalClass
|
coumarin derivative
|
|
gptkbp:color
|
varies by strength (e.g., pink, purple, blue, etc.)
|
|
gptkbp:contraindication
|
pregnancy
bleeding disorders
recent surgery
|
|
gptkbp:discoveredIn
|
1940s
|
|
gptkbp:eliminationHalfLife
|
20 to 60 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:form
|
gptkb:tablet
oral suspension
|
|
gptkbp:genericName
|
gptkb:warfarin
|
|
gptkbp:hasBoxedWarning
|
major or fatal bleeding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Coumadin
|
|
gptkbp:interactsWith
|
gptkb:vitamin_A
gptkb:NSAIDs
gptkb:aspirin
antibiotics
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
gptkb:Bristol-Myers_Squibb
|
|
gptkbp:mechanismOfAction
|
vitamin K antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:monitors
|
gptkb:INR_(International_Normalized_Ratio)
|
|
gptkbp:overdoseTreatment
|
gptkb:vitamin_A
fresh frozen plasma
prothrombin complex concentrate
|
|
gptkbp:pregnancyCategory
|
X
|
|
gptkbp:prescribes
|
adults
children (with caution)
|
|
gptkbp:requiresMonitoring
|
yes
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
bleeding
abdominal pain
bruising
|
|
gptkbp:storage
|
room temperature
|
|
gptkbp:usedFor
|
prevention of blood clots
prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
|
|
gptkbp:bfsParent
|
gptkb:warfarin
|
|
gptkbp:bfsLayer
|
5
|