Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:Coumadin
gptkb:Warfarin gptkb:warfarin |
| gptkbp:appointed_by |
oral tablet
|
| gptkbp:approves |
2000s
|
| gptkbp:brand |
gptkb:Jantoven
|
| gptkbp:clinical_trial |
prevent stroke in atrial fibrillation
prevent thromboembolic events treat venous thromboembolism |
| gptkbp:contraindication |
pregnancy
thrombocytopenia severe liver disease active bleeding severe hypertension recent surgery active peptic ulcer disease history of falls |
| gptkbp:dosage_form |
gptkb:tablet
|
| gptkbp:has_ability |
1 mg
5 mg 2 mg 3 mg 2.5 mg |
| https://www.w3.org/2000/01/rdf-schema#label |
Jantoven
|
| gptkbp:ingredients |
gptkb:warfarin
|
| gptkbp:interacts_with |
antibiotics
antifungals other anticoagulants NSAI Ds |
| gptkbp:is_monitored_by |
gptkb:INR
|
| gptkbp:is_used_for |
anticoagulation
|
| gptkbp:legal_issue |
prescription only
|
| gptkbp:manager |
oral
|
| gptkbp:manufacturer |
gptkb:Boehringer_Ingelheim
|
| gptkbp:packaging |
blister pack
|
| gptkbp:pharmacokinetics |
highly protein-bound
metabolized by liver half-life varies by individual vitamin K antagonist |
| gptkbp:scholarships |
regular blood tests required
avoid certain foods high in vitamin K do not stop taking without consulting a doctor inform healthcare providers of all medications report unusual bleeding or bruising |
| gptkbp:shelf_life |
varies by manufacturer
|
| gptkbp:side_effect |
nausea
allergic reaction bruising vomiting bleeding liver enzyme elevation skin rash hair loss gastrointestinal discomfort |
| gptkbp:storage |
room temperature
|