|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:CASNumber
|
gptkb:85898-30-2
|
|
gptkbp:category
|
cytokine
immune system protein
therapeutic protein
|
|
gptkbp:clinicalTrialPhase
|
immunotherapy
|
|
gptkbp:discoveredBy
|
gptkb:Tadahiko_Miyazaki
gptkb:Takashi_Taniguchi
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:EC_number
|
3.4.21.-
|
|
gptkbp:encodedBy
|
gptkb:IL2_gene
|
|
gptkbp:Entrez_Gene_ID
|
3558
|
|
gptkbp:expressedIn
|
lymphoid tissue
|
|
gptkbp:function
|
regulates immune response
stimulates growth of B cells
stimulates growth of T cells
stimulates growth of natural killer cells
|
|
gptkbp:GO
|
gptkb:GO:0005125
|
|
gptkbp:halfLife
|
7-10 minutes (in plasma)
|
|
gptkbp:hasApprovedDrug
|
gptkb:aldesleukin
|
|
gptkbp:HGNC_ID
|
6001
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Interleukin-2
|
|
gptkbp:length
|
153 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:4q27
|
|
gptkbp:MeSH_ID
|
gptkb:D015850
|
|
gptkbp:molecularWeight
|
15.5 kDa
|
|
gptkbp:OMIM
|
147680
|
|
gptkbp:PDB
|
gptkb:1M47
|
|
gptkbp:producedBy
|
activated T cells
|
|
gptkbp:promotion
|
gptkb:regulatory_T_cells
B cell antibody production
cytotoxic T lymphocytes
|
|
gptkbp:recipient
|
gptkb:IL-2_receptor
|
|
gptkbp:regulates
|
T cell proliferation
immune tolerance
apoptosis of immune cells
|
|
gptkbp:sideEffect
|
gptkb:capillary_leak_syndrome
fever
fatigue
chills
hypotension
|
|
gptkbp:structure
|
four alpha-helix bundle
|
|
gptkbp:symbol
|
gptkb:IL-2
|
|
gptkbp:UniProtID
|
gptkb:P60568
|
|
gptkbp:usedFor
|
renal cell carcinoma
metastatic melanoma
|
|
gptkbp:bfsParent
|
gptkb:Cetus_Corporation
|
|
gptkbp:bfsLayer
|
5
|