|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
gptkb:c-RAF
gptkb:RAF1
RAF1 kinase
|
|
gptkbp:associatedWith
|
gptkb:LEOPARD_syndrome
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:discoveredBy
|
H. R. H. M. Staal et al.
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:domain
|
gptkb:CR1_domain
gptkb:CR2_domain
gptkb:CR3_domain
regulatory domain
protein kinase domain
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:RAF1
5894
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
gptkbp:HGNC_ID
|
9829
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:OMIM
|
164760
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:3OMV
gptkb:4G0N
gptkb:6Q0J
|
|
gptkbp:phosphorylates
|
MAP2K1 (MEK1)
MAP2K2 (MEK2)
|
|
gptkbp:RefSeq
|
NM_002880
|
|
gptkbp:regulates
|
gptkb:RAS_proteins
cell differentiation
cell division
phosphorylation
protein-protein interactions
dephosphorylation
cell apoptosis
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
mitochondria
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
|
|
gptkbp:bfsLayer
|
7
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
proto-oncogene c-RAF
|