protein tyrosine phosphatase, receptor type C

URI: https://gptkb.org/entity/protein_tyrosine_phosphatase,_receptor_type_C
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alsoKnownAs gptkb:CD45
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:biologicalProcess protein tyrosine phosphatase activity
gptkbp:cellSurfaceMarker gptkb:leukocyte_common_antigen
gptkbp:encodedBy gptkb:PTPRC_gene
gptkbp:enzymeCommissionNumber EC 3.1.3.48
gptkbp:expressedIn hematopoietic cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of T- and B-cell antigen receptor signaling
dephosphorylation of tyrosine residues on proteins
gptkbp:gene gptkb:PTPRC
gptkbp:hasRole signal transduction
lymphocyte activation
gptkbp:HGNC_ID 9666
https://www.w3.org/2000/01/rdf-schema#label protein tyrosine phosphatase, receptor type C
gptkbp:interactsWith gptkb:Fyn
gptkb:ZAP-70
gptkb:Lck
gptkbp:involves immune response
gptkbp:locatedOnChromosome 1q31-q32
gptkbp:mutationAssociatedWith immunodeficiency
gptkbp:OMIM 151460
gptkbp:orthologInMouse gptkb:Ptprc
gptkbp:PDB 1YGU
gptkbp:RefSeq NP_002828
gptkbp:structure extracellular domain, single transmembrane region, two intracellular phosphatase domains
gptkbp:target autoantibodies in some autoimmune diseases
gptkbp:UniProtID P08575
gptkbp:used_as_marker_for leukocytes in flow cytometry
gptkbp:bfsParent gptkb:PTPRC
gptkbp:bfsLayer 7