phosphoinositide-3-kinase gamma

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	gptkb:G_protein-coupled_receptors gptkb:Gβγ_subunits
gptkbp:alternativeName	gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_gamma_isoform gptkb:PI3-kinase_gamma gptkb:PI3Kγ
gptkbp:associatedWith	gptkb:cancer inflammatory diseases
gptkbp:biologicalProcess	signal transduction kinase activity inflammatory response chemotaxis
gptkbp:catalyzes	phosphorylation of phosphatidylinositol-4,5-bisphosphate
gptkbp:cellularComponent	gptkb:cytoplasm gptkb:plasma_membrane
gptkbp:EC_number	2.7.1.153
gptkbp:encodedBy	gptkb:PIK3CG_gene
gptkbp:Entrez_Gene_ID	5294
gptkbp:expressedIn	gptkb:leukocytes heart endothelial cells
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:gene	gptkb:PIK3CG
gptkbp:inhibitedBy	gptkb:LY294002 gptkb:wortmannin
gptkbp:involves	gptkb:immune_response asthma autoimmune diseases cell signaling allergic response
gptkbp:locatedOnChromosome	7q22.3
gptkbp:member	class IB PI3Ks
gptkbp:orthologInMouse	gptkb:Pik3cg
gptkbp:PDB	1E8X
gptkbp:phosphorylates	phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol-3,4,5-trisphosphate
gptkbp:regulates	T cell activation neutrophil migration cardiac contractility
gptkbp:regulatory_subunit	gptkb:p101 gptkb:p84
gptkbp:subunit	gptkb:p110γ
gptkbp:target	drug development
gptkbp:UniProtID	gptkb:P48736
gptkbp:bfsParent	gptkb:PIK3CG_(p110γ)
gptkbp:bfsLayer	7
http://www.w3.org/2000/01/rdf-schema#label	phosphoinositide-3-kinase gamma