phosphoinositide-3-kinase gamma

URI: https://gptkb.org/entity/phosphoinositide-3-kinase_gamma
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:G_protein-coupled_receptors
gptkb:Gβγ_subunits
gptkbp:alternativeName gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_gamma_isoform
gptkb:PI3-kinase_gamma
gptkb:PI3Kγ
gptkbp:associatedWith gptkb:cancer
inflammatory diseases
gptkbp:biologicalProcess signal transduction
kinase activity
inflammatory response
chemotaxis
gptkbp:catalyzes phosphorylation of phosphatidylinositol-4,5-bisphosphate
gptkbp:cellularComponent gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:EC_number 2.7.1.153
gptkbp:encodedBy gptkb:PIK3CG_gene
gptkbp:Entrez_Gene_ID 5294
gptkbp:expressedIn gptkb:leukocytes
heart
endothelial cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:gene gptkb:PIK3CG
https://www.w3.org/2000/01/rdf-schema#label phosphoinositide-3-kinase gamma
gptkbp:inhibitedBy gptkb:LY294002
gptkb:wortmannin
gptkbp:involves asthma
autoimmune diseases
cell signaling
immune response
allergic response
gptkbp:locatedOnChromosome 7q22.3
gptkbp:member class IB PI3Ks
gptkbp:orthologInMouse gptkb:Pik3cg
gptkbp:PDB 1E8X
gptkbp:phosphorylates phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol-3,4,5-trisphosphate
gptkbp:regulates T cell activation
neutrophil migration
cardiac contractility
gptkbp:regulatory_subunit gptkb:p101
gptkb:p84
gptkbp:subunit gptkb:p110γ
gptkbp:target drug development
gptkbp:UniProtID gptkb:P48736
gptkbp:bfsParent gptkb:PIK3CG_(p110γ)
gptkbp:bfsLayer 6