|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
G-protein coupled receptors
|
|
gptkbp:alternativeName
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_gamma_isoform
gptkb:PIK3CG
|
|
gptkbp:associatedWith
|
gptkb:cancer
cardiovascular diseases
inflammatory diseases
|
|
gptkbp:catalyzes
|
phosphorylation of phosphatidylinositol (4,5)-bisphosphate
|
|
gptkbp:EC_number
|
2.7.1.153
|
|
gptkbp:encodedBy
|
gptkb:PIK3CG_gene
|
|
gptkbp:Entrez_Gene_ID
|
5294
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
|
|
gptkbp:familyMember
|
phosphoinositide 3-kinases
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:hasBiologicalActivity
|
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity
|
|
gptkbp:hasCatalyticSubunit
|
gptkb:p110γ
|
|
gptkbp:hasRegulatorySubunit
|
gptkb:p101
gptkb:p84
|
|
gptkbp:hasRole
|
inflammation
cardiac function
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3Kγ
|
|
gptkbp:inhibitedBy
|
gptkb:LY294002
gptkb:wortmannin
|
|
gptkbp:involvedIn
|
cell signaling
immune response
chemotaxis
|
|
gptkbp:locatedOnChromosome
|
7q22.3
|
|
gptkbp:molecularWeight
|
126 kDa (p110γ subunit)
|
|
gptkbp:OMIM
|
602838
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
Chemokine signaling pathway
Leukocyte transendothelial migration
|
|
gptkbp:PDB
|
2CHX
6AUD
|
|
gptkbp:produces
|
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:subunit
|
gptkb:Class_IB_PI3K
|
|
gptkbp:UniProtID
|
gptkb:P48736
|
|
gptkbp:bfsParent
|
gptkb:Class_IB_PI3K
gptkb:PIK3CG_(p110γ)
gptkb:Pik3cg
|
|
gptkbp:bfsLayer
|
6
|