pentameric ligand-gated ion channels

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:Cys-loop_receptors gptkb:pLGICs
gptkbp:domain	gptkb:Cys-loop
gptkbp:evolvesFrom	ancient
gptkbp:example	gptkb:zebrafish_glycine_receptor gptkb:GABA_A_receptor gptkb:glycine_receptor gptkb:serotonin_5-HT3_receptor nicotinic acetylcholine receptor
gptkbp:foundIn	animals prokaryotes
gptkbp:function	mediate fast synaptic transmission
https://www.w3.org/2000/01/rdf-schema#label	pentameric ligand-gated ion channels
gptkbp:location	gptkb:cell_membrane
gptkbp:mechanismOfAction	ligand binding opens ion channel
gptkbp:modulatedBy	gptkb:beer gptkb:benzodiazepines drugs barbiturates insecticides antipsychotics anticonvulsants neurotransmitters antidepressants anesthetics
gptkbp:mutationAssociatedWith	gptkb:depression gptkb:congenital_myasthenic_syndromes gptkb:myasthenia_gravis gptkb:autism_spectrum_disorder epilepsy schizophrenia insomnia anxiety disorders hyperekplexia alcohol dependence
gptkbp:permeableTo	cations or anions
gptkbp:proteinFamily	gptkb:CHRNA gptkb:GABRA gptkb:GLRA gptkb:HTR3A
gptkbp:role	gptkb:synaptic_plasticity gptkb:nervous_system signal transduction muscle contraction inhibitory neurotransmission excitatory neurotransmission
gptkbp:structure	pentameric
gptkbp:subunit	gptkb:government_agency alpha beta gamma epsilon
gptkbp:subunitCount	5
gptkbp:superfamily	gptkb:ligand-gated_ion_channels
gptkbp:bfsParent	gptkb:Cys-loop_receptor_family
gptkbp:bfsLayer	6