|
gptkbp:instanceOf
|
gptkb:voltage-gated_potassium_channel
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:gamma-aminobutyric_acid
|
|
gptkbp:discoveredBy
|
gptkb:Nico_van_Gelder
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:encodedBy
|
gptkb:GABRA1_gene
gptkb:GABRB2_gene
gptkb:GABRG2_gene
|
|
gptkbp:enemyOf
|
gptkb:bicuculline
gptkb:muscimol
gptkb:THIP
gptkb:isoguvacine
gptkb:picrotoxin
|
|
gptkbp:foundIn
|
central nervous system
|
|
gptkbp:function
|
mediates inhibitory neurotransmission
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GABA A receptor
|
|
gptkbp:inhibitedBy
|
gptkb:flumazenil
gptkb:gabazine
|
|
gptkbp:location
|
postsynaptic membrane
|
|
gptkbp:modulatedBy
|
gptkb:benzodiazepines
ethanol
barbiturates
general anesthetics
neurosteroids
|
|
gptkbp:permeableTo
|
chloride ions
|
|
gptkbp:relatedTo
|
gptkb:GABA_B_receptor
gptkb:GABA_C_receptor
|
|
gptkbp:role
|
gptkb:center
gptkb:depression
gptkb:autism_spectrum_disorder
epilepsy
schizophrenia
muscle relaxation
insomnia
anxiety disorders
sedation
anticonvulsant effect
sleep regulation
alcohol dependence
anxiolysis
|
|
gptkbp:structure
|
pentameric
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
gamma subunit
delta subunit
epsilon subunit
pi subunit
rho subunit
theta subunit
|
|
gptkbp:bfsParent
|
gptkb:muscimol
gptkb:GABA
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsLayer
|
5
|